Seroatlas · Human Serome Atlas

KCNK7

Potassium channel subfamily K member 7

Also known as: K2p7.1, KCNK7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2U2
Gene: KCNK7
Ensembl: ENSG00000173338
Chromosome: 11
Canonical length: 307 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Voltage-gated ion channels
Subcellular location: Plasma membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; however, it may require other non-pore-forming proteins for activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

307 residues, UniProt reviewed canonical sequence.

>Q9Y2U2|KCNK7
     1  MGGLRPWSRY GLLVVAHLLA LGLGAVVFQA LEGPPACRLQ AELRAELAAF QAEHRACLPP
    61  GALEELLGTA LATQAHGVST LGNSSEGRTW DLPSALLFAA SILTTTGYGH MAPLSPGGKA
   121  FCMVYAALGL PASLALVATL RHCLLPVLSR PRAWVAVHWQ LSPARAALLQ AVALGLLVAS
   181  SFVLLPALVL WGLQGDCSLL GAVYFCFSSL STIGLEDLLP GRGRSLHPVI YHLGQLALLG
   241  YLLLGLLAML LAVETFSELP QVRAMGKFFR PSGPVTAEDQ GGILGQDELA LSTLPPAAPA
   301  SGQAPAC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNK7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 89 nTPM

Expression across tissuesHPA

Tissue

skin: 89 nTPM
esophagus: 18 nTPM
vagina: 8.9 nTPM
cervix: 5.5 nTPM
bone marrow: 5.1 nTPM
cerebellum: 4.7 nTPM

Single-cell type

esophageal suprabasal cells: 129 nCPM
suprabasal keratinocytes: 108 nCPM
esophageal basal cells: 53 nCPM
esophageal apical cells: 30 nCPM
basal keratinocytes: 18 nCPM
neutrophils: 8.2 nCPM

Immune cell

naive B-cell: 2.2 nTPM
basophil: 2.1 nTPM
neutrophil: 1.5 nTPM
classical monocyte: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM

Brain region

cerebellum: 4.1 nTPM
white matter: 4 nTPM
cerebral cortex: 3.5 nTPM
pons: 3.3 nTPM
basal ganglia: 3 nTPM
medulla oblongata: 3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0
gnomAD missense Z: 0.06
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNK7 as an antibody target. Whether an autoantibody or antibody against KCNK7 could matter depends on whether native KCNK7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNK7 is annotated at the cell surface, where native KCNK7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNK7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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