Seroatlas · Human Serome Atlas

KCNK6

Potassium channel subfamily K member 6

Also known as: K2p6.1, KCNK6_HUMAN, TWIK-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y257
Gene
KCNK6
Ensembl
ENSG00000099337
Chromosome
19
Canonical length
313 aa
Protein class
Predicted membrane proteins, Transporters, Voltage-gated ion channels
Subcellular location
Plasma membrane,Actin filaments,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>Q9Y257|KCNK6
     1  MRRGALLAGA LAAYAAYLVL GALLVARLEG PHEARLRAEL ETLRAQLLQR SPCVAAPALD
    61  AFVERVLAAG RLGRVVLANA SGSANASDPA WDFASALFFA STLITTVGYG YTTPLTDAGK
   121  AFSIAFALLG VPTTMLLLTA SAQRLSLLLT HVPLSWLSMR WGWDPRRAAC WHLVALLGVV
   181  VTVCFLVPAV IFAHLEEAWS FLDAFYFCFI SLSTIGLGDY VPGEAPGQPY RALYKVLVTV
   241  YLFLGLVAMV LVLQTFRHVS DLHGLTELIL LPPPCPASFN ADEDDRVDIL GPQPESHQQL
   301  SASSHTDYAS IPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNK6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 30 nTPM
  • cervix: 26 nTPM
  • endometrium: 21 nTPM
  • blood vessel: 19 nTPM
  • skin: 18 nTPM
  • vagina: 18 nTPM

Single-cell type

  • esophageal apical cells: 339 nCPM
  • decidual stromal cells: 254 nCPM
  • breast lactating cells: 251 nCPM
  • esophageal suprabasal cells: 164 nCPM
  • platelets: 160 nCPM
  • suprabasal keratinocytes: 154 nCPM

Immune cell

  • basophil: 26 nTPM
  • eosinophil: 16 nTPM
  • myeloid DC: 11 nTPM
  • non-classical monocyte: 7.2 nTPM
  • classical monocyte: 6.9 nTPM
  • intermediate monocyte: 6.2 nTPM

Brain region

  • white matter: 11 nTPM
  • cerebral cortex: 9.7 nTPM
  • medulla oblongata: 9.7 nTPM
  • pons: 9.4 nTPM
  • thalamus: 9.4 nTPM
  • amygdala: 9.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.34
gnomAD pLI
0
gnomAD missense Z
0.03
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNK6 as an antibody target. Whether an autoantibody or antibody against KCNK6 could matter depends on whether native KCNK6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNK6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KCNK6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNK6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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