Seroatlas · Human Serome Atlas

KCNK5

Potassium channel subfamily K member 5

Also known as: K2p5.1, KCNK5_HUMAN, TASK-2, TASK2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95279
Gene
KCNK5
Ensembl
ENSG00000164626
Chromosome
6
Canonical length
499 aa
Protein class
Predicted membrane proteins, Transporters, Voltage-gated ion channels
Subcellular location
Nucleoplasm
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

499 residues, UniProt reviewed canonical sequence.

>O95279|KCNK5
     1  MVDRGPLLTS AIIFYLAIGA AIFEVLEEPH WKEAKKNYYT QKLHLLKEFP CLGQEGLDKI
    61  LEVVSDAAGQ GVAITGNQTF NNWNWPNAMI FAATVITTIG YGNVAPKTPA GRLFCVFYGL
   121  FGVPLCLTWI SALGKFFGGR AKRLGQFLTK RGVSLRKAQI TCTVIFIVWG VLVHLVIPPF
   181  VFMVTEGWNY IEGLYYSFIT ISTIGFGDFV AGVNPSANYH ALYRYFVELW IYLGLAWLSL
   241  FVNWKVSMFV EVHKAIKKRR RRRKESFESS PHSRKALQVK GSTASKDVNI FSFLSKKEET
   301  YNDLIKQIGK KAMKTSGGGE TGPGPGLGPQ GGGLPALPPS LVPLVVYSKN RVPTLEEVSQ
   361  TLRSKGHVSR SPDEEAVARA PEDSSPAPEV FMNQLDRISE ECEPWDAQDY HPLIFQDASI
   421  TFVNTEAGLS DEETSKSSLE DNLAGEESPQ QGAEAKAPLN MGEFPSSSES TFTSTESELS
   481  VPYEQLMNEY NKANSPKGT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNK5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 34 nTPM
  • small intestine: 33 nTPM
  • skin: 28 nTPM
  • duodenum: 27 nTPM
  • salivary gland: 26 nTPM
  • liver: 24 nTPM

Single-cell type

  • proximal tubule cells: 354 nCPM
  • enterocytes: 241 nCPM
  • salivary duct cells: 221 nCPM
  • salivary ionocytes: 108 nCPM
  • colonocytes: 82 nCPM
  • salivary basal cells: 80 nCPM

Immune cell

  • gdT-cell: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • plasmacytoid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • thalamus: 0.6 nTPM
  • midbrain: 0.5 nTPM
  • hypothalamus: 0.4 nTPM
  • medulla oblongata: 0.4 nTPM
  • amygdala: 0.3 nTPM
  • choroid plexus: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.53
gnomAD pLI
0.33
gnomAD missense Z
1.97
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNK5 as an antibody target. Whether an autoantibody or antibody against KCNK5 could matter depends on whether native KCNK5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNK5 is annotated at the cell surface, where native KCNK5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNK5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNK5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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