Seroatlas · Human Serome Atlas

KCNK4

Potassium channel subfamily K member 4

Also known as: K2p4.1, KCNK4_HUMAN, TRAAK

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NYG8
Gene
KCNK4
Ensembl
ENSG00000182450
Chromosome
11
Canonical length
393 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Voltage-gated ion channels
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

393 residues, UniProt reviewed canonical sequence.

>Q9NYG8|KCNK4
     1  MRSTTLLALL ALVLLYLVSG ALVFRALEQP HEQQAQRELG EVREKFLRAH PCVSDQELGL
    61  LIKEVADALG GGADPETNST SNSSHSAWDL GSAFFFSGTI ITTIGYGNVA LRTDAGRLFC
   121  IFYALVGIPL FGILLAGVGD RLGSSLRHGI GHIEAIFLKW HVPPELVRVL SAMLFLLIGC
   181  LLFVLTPTFV FCYMEDWSKL EAIYFVIVTL TTVGFGDYVA GADPRQDSPA YQPLVWFWIL
   241  LGLAYFASVL TTIGNWLRVV SRRTRAEMGG LTAQAASWTG TVTARVTQRA GPAAPPPEKE
   301  QPLLPPPPCP AQPLGRPRSP SPPEKAQPPS PPTASALDYP SENLAFIDES SDTQSERGCP
   361  LPRAPRGRRR PNPPRKPVRP RGPGRPRDKG VPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNK4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • amygdala: 13 nTPM
  • basal ganglia: 13 nTPM
  • hippocampal formation: 13 nTPM
  • cerebral cortex: 11 nTPM
  • hypothalamus: 3.3 nTPM
  • midbrain: 1.5 nTPM

Single-cell type

  • brain excitatory neurons: 11 nCPM
  • brain inhibitory neurons: 7 nCPM
  • other brain neurons: 5.7 nCPM
  • astrocytes: 3.7 nCPM
  • oligodendrocyte progenitor cells: 2 nCPM
  • oligodendrocytes: 1.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 20 nTPM
  • hippocampal formation: 18 nTPM
  • amygdala: 17 nTPM
  • basal ganglia: 13 nTPM
  • white matter: 11 nTPM
  • thalamus: 7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KCNK4.

Disease | AllUniProt

Conditions KCNK4 is implicated in, by any mechanism.

  • Facial dysmorphism, hypertrichosis, epilepsy, intellectual and developmental delay, and gingival overgrowth syndrome (FHEIG) MIM:618381

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 481 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0.01
gnomAD missense Z
0.75
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNK4 as an antibody target. Whether an autoantibody or antibody against KCNK4 could matter depends on whether native KCNK4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNK4 is annotated at the cell surface, where native KCNK4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNK4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNK4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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