Seroatlas · Human Serome Atlas

KCNK17

Potassium channel subfamily K member 17

Also known as: K2p17.1, KCNKH_HUMAN, TALK-2, TALK2, TASK-4, TASK4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96T54
Gene: KCNK17
Ensembl: ENSG00000124780
Chromosome: 6
Canonical length: 332 aa
Protein class: Predicted membrane proteins, Transporters, Voltage-gated ion channels
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Canonical amino-acid sequenceUniProt

332 residues, UniProt reviewed canonical sequence.

>Q96T54|KCNK17
     1  MYRPRARAAP EGRVRGCAVP STVLLLLAYL AYLALGTGVF WTLEGRAAQD SSRSFQRDKW
    61  ELLQNFTCLD RPALDSLIRD VVQAYKNGAS LLSNTTSMGR WELVGSFFFS VSTITTIGYG
   121  NLSPNTMAAR LFCIFFALVG IPLNLVVLNR LGHLMQQGVN HWASRLGGTW QDPDKARWLA
   181  GSGALLSGLL LFLLLPPLLF SHMEGWSYTE GFYFAFITLS TVGFGDYVIG MNPSQRYPLW
   241  YKNMVSLWIL FGMAWLALII KLILSQLETP GRVCSCCHHS SKEDFKSQSW RQGPDREPES
   301  HSPQQGCYPE GPMGIIQHLE PSAHAAGCGK DS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNK17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 27 nTPM
lung: 8 nTPM
thyroid gland: 6.8 nTPM
heart muscle: 6.3 nTPM
liver: 4.2 nTPM
pancreas: 4.1 nTPM

Single-cell type

thymocytes: 47 nCPM
pancreatic islet cells: 38 nCPM
pdcs: 33 nCPM
pericytes: 20 nCPM
hepatic stellate cells: 19 nCPM
epididymal efferent duct absorptive cells: 10 nCPM

Immune cell

plasmacytoid DC: 64 nTPM
NK-cell: 1.8 nTPM
total PBMC: 0.3 nTPM
eosinophil: 0.2 nTPM
myeloid DC: 0.2 nTPM
basophil: 0.1 nTPM

Brain region

medulla oblongata: 1.2 nTPM
midbrain: 1.2 nTPM
thalamus: 1.2 nTPM
basal ganglia: 1.1 nTPM
cerebral cortex: 1 nTPM
cerebellum: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0
gnomAD missense Z: 0.2
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNK17 as an antibody target. Whether an autoantibody or antibody against KCNK17 could matter depends on whether native KCNK17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNK17 is annotated at the cell surface, where native KCNK17 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNK17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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