Seroatlas · Human Serome Atlas

KCNK16

Potassium channel subfamily K member 16

Also known as: K2p16.1, KCNKG_HUMAN, TALK-1, TALK1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96T55
Gene: KCNK16
Ensembl: ENSG00000095981
Chromosome: 6
Canonical length: 309 aa
Protein class: Predicted membrane proteins, Transporters, Voltage-gated ion channels
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>Q96T55|KCNK16
     1  MPSAGLCSCW GGRVLPLLLA YVCYLLLGAT IFQLLERQAE AQSRDQFQLE KLRFLENYTC
    61  LDQWAMEQFV QVIMEAWVKG VNPKGNSTNP SNWDFGSSFF FAGTVVTTIG YGNLAPSTEA
   121  GQVFCVFYAL LGIPLNVIFL NHLGTGLRAH LAAIERWEDR PRRSQVLQVL GLALFLTLGT
   181  LVILIFPPMV FSHVEGWSFS EGFYFAFITL STIGFGDYVV GTDPSKHYIS VYRSLAAIWI
   241  LLGLAWLALI LPLGPLLLHR CCQLWLLSLR QGCGAKAAPG RRPRRGSTAA RGVQVTPQDF
   301  PISKKGLGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNK16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

pancreas: 22 nTPM
stomach: 9.8 nTPM
duodenum: 3.4 nTPM
small intestine: 0.9 nTPM
thyroid gland: 0.9 nTPM
lung: 0.1 nTPM

Single-cell type

pancreatic islet cells: 81 nCPM
oocytes: 4.6 nCPM
neuroendocrine cells: 2.5 nCPM
pancreatic acinar cells: 0.3 nCPM
endometrial ciliated cells: 0.2 nCPM
monocytes: 0.2 nCPM

Immune cell

basophil: 2.1 nTPM
NK-cell: 0.2 nTPM
plasmacytoid DC: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

medulla oblongata: 0.3 nTPM
midbrain: 0.3 nTPM
thalamus: 0.3 nTPM
basal ganglia: 0.2 nTPM
cerebral cortex: 0.2 nTPM
hypothalamus: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0
gnomAD missense Z: 0.91
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNK16 as an antibody target. Whether an autoantibody or antibody against KCNK16 could matter depends on whether native KCNK16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNK16 is annotated at the cell surface, where native KCNK16 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNK16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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