KCNK15
Potassium channel subfamily K member 15
Also known as: dJ781B1.1, K2p15.1, KCNK11, KCNK14, KCNKF_HUMAN, KIAA0237, KT3.3, TASK-5, TASK5
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H427
- Gene
- KCNK15
- Ensembl
- ENSG00000124249
- Chromosome
- 20
- Canonical length
- 330 aa
- Protein class
- Predicted membrane proteins, Transporters, Voltage-gated ion channels
OverviewNCBI Gene
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
330 residues, UniProt reviewed canonical sequence.
>Q9H427|KCNK15
1 MRRPSVRAAG LVLCTLCYLL VGAAVFDALE SEAESGRQRL LVQKRGALRR KFGFSAEDYR
61 ELERLALQAE PHRAGRQWKF PGSFYFAITV ITTIEYGHAA PGTDSGKVFC MFYALLGIPL
121 TLVTFQSLGE RLNAVVRRLL LAAKCCLGLR WTCVSTENLV VAGLLACAAT LALGAVAFSH
181 FEGWTFFHAY YYCFITLTTI GFGDFVALQS GEALQRKLPY VAFSFLYILL GLTVIGAFLN
241 LVVLRFLVAS ADWPERAART PSPRPPGAPE SRGLWLPRRP ARSVGSASVF CHVHKLERCA
301 RDNLGFSPPS SPGVVRGGQA PRLGARWKSILocalizationUniProt · AlphaFold · HPA
Whether an antibody against KCNK15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.44
- Highest tissue expression
- 23 nTPM
Expression across tissuesHPA
Tissue
- blood vessel: 23 nTPM
- fallopian tube: 5 nTPM
- basal ganglia: 4.1 nTPM
- adipose tissue: 3.9 nTPM
- pituitary gland: 3.5 nTPM
- testis: 3.5 nTPM
Single-cell type
- epididymal efferent duct absorptive cells: 133 nCPM
- fallopian secretory cells: 122 nCPM
- gastric chief cells: 26 nCPM
- epididymal efferent duct ciliated cells: 26 nCPM
- mesothelial cells: 18 nCPM
- pancreatic duct cells: 14 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- hypothalamus: 2.6 nTPM
- basal ganglia: 1.8 nTPM
- cerebral cortex: 1.6 nTPM
- midbrain: 1.3 nTPM
- choroid plexus: 1.2 nTPM
- amygdala: 1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.25
- gnomAD pLI
- 0.03
- gnomAD missense Z
- 0.78
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Two pore domain potassium channel, TASK family
- Two pore domain potassium channel
- Potassium channel domain
- Ion channel
- Potassium channel subfamily K member 15
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads KCNK15 as an antibody target. Whether an autoantibody or antibody against KCNK15 could matter depends on whether native KCNK15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
KCNK15 is annotated at the cell surface, where native KCNK15 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label KCNK15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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