Seroatlas · Human Serome Atlas

KCNK13

Potassium channel subfamily K member 13

Also known as: K2p13.1, KCNKD_HUMAN, THIK-1, THIK1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HB14
Gene
KCNK13
Ensembl
ENSG00000152315
Chromosome
14
Canonical length
408 aa
Protein class
Predicted membrane proteins, Voltage-gated ion channels
Subcellular location
Nuclear speckles,Cell Junctions
Quaternary structure
Homodimer

OverviewNCBI Gene

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a potassium channel containing two pore-forming domains. This protein is an open channel that can be stimulated by arachidonic acid and inhibited by the anesthetic halothane. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

408 residues, UniProt reviewed canonical sequence.

>Q9HB14|KCNK13
     1  MAGRGFSWGP GHLNEDNARF LLLAALIVLY LLGGAAVFSA LELAHERQAK QRWEERLANF
    61  SRGHNLSRDE LRGFLRHYEE ATRAGIRVDN VRPRWDFTGA FYFVGTVVST IGFGMTTPAT
   121  VGGKIFLIFY GLVGCSSTIL FFNLFLERLI TIIAYIMKSC HQRQLRRRGA LPQESLKDAG
   181  QCEVDSLAGW KPSVYYVMLI LCTASILISC CASAMYTPIE GWSYFDSLYF CFVAFSTIGF
   241  GDLVSSQNAH YESQGLYRFA NFVFILMGVC CIYSLFNVIS ILIKQSLNWI LRKMDSGCCP
   301  QCQRGLLRSR RNVVMPGSVR NRCNISIETD GVAESDTDGR RLSGEMISMK DLLAANKASL
   361  AILQKQLSEM ANGCPHQTST LARDNEFSGG VGAFAIMNNR LAETSGDR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNK13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
9.5 nTPM

Expression across tissuesHPA

Tissue

  • testis: 9.5 nTPM
  • parathyroid gland: 5.7 nTPM
  • choroid plexus: 4.1 nTPM
  • kidney: 4 nTPM
  • thyroid gland: 1.8 nTPM
  • heart muscle: 1.7 nTPM

Single-cell type

  • sertoli cells: 300 nCPM
  • microglia: 266 nCPM
  • choroid plexus epithelial cells: 265 nCPM
  • renal connecting tubule cells: 128 nCPM
  • cdc: 76 nCPM
  • ependymal cells: 75 nCPM

Immune cell

  • myeloid DC: 1.2 nTPM
  • classical monocyte: 0.4 nTPM
  • intermediate monocyte: 0.4 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • non-classical monocyte: 0.1 nTPM
  • total PBMC: 0.1 nTPM

Brain region

  • choroid plexus: 12 nTPM
  • white matter: 7.1 nTPM
  • midbrain: 4.9 nTPM
  • thalamus: 4.9 nTPM
  • cerebral cortex: 4 nTPM
  • spinal cord: 4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KCNK13.

Disease | ImmuneIEDB

Conditions an epitope on KCNK13 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.8
gnomAD pLI
0.05
gnomAD missense Z
0.74
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNK13 as an antibody target. Whether an autoantibody or antibody against KCNK13 could matter depends on whether native KCNK13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNK13 is annotated at the cell surface, where native KCNK13 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNK13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNK13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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