Seroatlas · Human Serome Atlas

KCNK12

Potassium channel subfamily K member 12

Also known as: K2p12.1, KCNKC_HUMAN, THIK-2, THIK2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HB15
Gene: KCNK12
Ensembl: ENSG00000184261
Chromosome: 2
Canonical length: 430 aa
Protein class: Predicted membrane proteins, Voltage-gated ion channels
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

430 residues, UniProt reviewed canonical sequence.

>Q9HB15|KCNK12
     1  MSSRSPRPPP RRSRRRLPRP SCCCCCCRRS HLNEDTGRFV LLAALIGLYL VAGATVFSAL
    61  ESPGEAEARA RWGATLRNFS AAHGVAEPEL RAFLRHYEAA LAAGVRADAL RPRWDFPGAF
   121  YFVGTVVSTI GFGMTTPATV GGKAFLIAYG LFGCAGTILF FNLFLERIIS LLAFIMRACR
   181  ERQLRRSGLL PATFRRGSAL SEADSLAGWK PSVYHVLLIL GLFAVLLSCC ASAMYTSVEG
   241  WDYVDSLYFC FVTFSTIGFG DLVSSQHAAY RNQGLYRLGN FLFILLGVCC IYSLFNVISI
   301  LIKQVLNWML RKLSCRCCAR CCPAPGAPLA RRNAITPGSR LRRRLAALGA DPAARDSDAE
   361  GRRLSGELIS MRDLTASNKV SLALLQKQLS ETANGYPRSV CVNTRQNGFS GGVGALGIMN
   421  NRLAETSASR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNK12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 10 nTPM
spinal cord: 4.2 nTPM
cerebral cortex: 3.8 nTPM
amygdala: 2.1 nTPM
pituitary gland: 1.7 nTPM
hippocampal formation: 1.5 nTPM

Single-cell type

extravillous trophoblasts: 65 nCPM
lactotrophs: 50 nCPM
somatotrophs: 50 nCPM
brain excitatory neurons: 43 nCPM
thyrotrophs: 39 nCPM
epicardial cells: 32 nCPM

Immune cell

memory CD8 T-cell: 0.1 nTPM
T-reg: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 20 nTPM
cerebral cortex: 18 nTPM
pons: 12 nTPM
medulla oblongata: 11 nTPM
white matter: 11 nTPM
amygdala: 9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.37
gnomAD pLI: 0.92
gnomAD missense Z: 3.65
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

potassium ion transmembrane transport

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNK12 as an antibody target. Whether an autoantibody or antibody against KCNK12 could matter depends on whether native KCNK12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNK12 is annotated at the cell surface, where native KCNK12 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNK12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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