Seroatlas · Human Serome Atlas

KCNK10

Potassium channel subfamily K member 10

Also known as: K2p10.1, KCNKA_HUMAN, PPP1R97, TREK-2, TREK2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P57789
Gene
KCNK10
Ensembl
ENSG00000100433
Chromosome
14
Canonical length
538 aa
Protein class
Predicted membrane proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]

Canonical amino-acid sequenceUniProt

538 residues, UniProt reviewed canonical sequence.

>P57789|KCNK10
     1  MFFLYTDFFL SLVAVPAAAP VCQPKSATNG QPPAPAPTPT PRLSISSRAT VVARMEGTSQ
    61  GGLQTVMKWK TVVAIFVVVV VYLVTGGLVF RALEQPFESS QKNTIALEKA EFLRDHVCVS
   121  PQELETLIQH ALDADNAGVS PIGNSSNNSS HWDLGSAFFF AGTVITTIGY GNIAPSTEGG
   181  KIFCILYAIF GIPLFGFLLA GIGDQLGTIF GKSIARVEKV FRKKQVSQTK IRVISTILFI
   241  LAGCIVFVTI PAVIFKYIEG WTALESIYFV VVTLTTVGFG DFVAGGNAGI NYREWYKPLV
   301  WFWILVGLAY FAAVLSMIGD WLRVLSKKTK EEVGEIKAHA AEWKANVTAE FRETRRRLSV
   361  EIHDKLQRAA TIRSMERRRL GLDQRAHSLD MLSPEKRSVF AALDTGRFKA SSQESINNRP
   421  NNLRLKGPEQ LNKHGQGASE DNIINKFGST SRLTKRKNKD LKKTLPEDVQ KIYKTFRNYS
   481  LDEEKKEEET EKMCNSDNSS TAMLTDCIQQ HAELENGMIP TDTKDREPEN NSLLEDRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNK10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
4.8 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 4.8 nTPM
  • cerebellum: 3.8 nTPM
  • hippocampal formation: 3.4 nTPM
  • amygdala: 3.3 nTPM
  • basal ganglia: 3.1 nTPM
  • cerebral cortex: 3 nTPM

Single-cell type

  • pdcs: 142 nCPM
  • brain excitatory neurons: 58 nCPM
  • oligodendrocytes: 53 nCPM
  • oligodendrocyte progenitor cells: 47 nCPM
  • basal keratinocytes: 34 nCPM
  • other brain neurons: 26 nCPM

Immune cell

  • plasmacytoid DC: 10 nTPM
  • myeloid DC: 0.1 nTPM
  • total PBMC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • cerebellum: 16 nTPM
  • white matter: 15 nTPM
  • cerebral cortex: 14 nTPM
  • medulla oblongata: 14 nTPM
  • pons: 14 nTPM
  • basal ganglia: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.67
gnomAD pLI
0
gnomAD missense Z
1.32
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNK10 as an antibody target. Whether an autoantibody or antibody against KCNK10 could matter depends on whether native KCNK10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNK10 is annotated at the cell surface, where native KCNK10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNK10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNK10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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