Seroatlas · Human Serome Atlas

KCNJ5-AS1

Uncharacterized protein KCNJ5-AS1

Also known as: KC5S1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAV5
Gene: KCNJ5-AS1
Canonical length: 145 aa

OverviewNCBI Gene

No narrative summary is available for KCNJ5-AS1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

145 residues, UniProt reviewed canonical sequence.

>Q8TAV5|KCNJ5-AS1
     1  MLTRLVLSAH LSSTTSPPWT HAAISWELDN VLMPSPRIWP QVTPTGRSAS VRSEGNTSSL
    61  WNFSAGQDVH AIVTRTCESV LSSAVYTHGC GCVRSATNIT CQSSGQQRQA ARQEEENSIC
   121  KAHDSREGRL GYPLSAHQPG SGGPN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNJ5-AS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF5570
Family of unknown function (DUF5570)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNJ5-AS1 as an antibody target. Whether an autoantibody or antibody against KCNJ5-AS1 could matter depends on whether native KCNJ5-AS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNJ5-AS1 is annotated as secreted, so native KCNJ5-AS1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label KCNJ5-AS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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