Seroatlas · Human Serome Atlas

KCNH6

Voltage-gated inwardly rectifying potassium channel KCNH6

Also known as: erg2, HERG2, KCNH6_HUMAN, Kv11.2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H252
Gene
KCNH6
Ensembl
ENSG00000173826
Chromosome
17
Canonical length
958 aa
Protein class
FDA approved drug targets, Predicted membrane proteins, Voltage-gated ion channels

OverviewNCBI Gene

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

958 residues, UniProt reviewed canonical sequence.

>Q9H252|KCNH6
     1  MPVRRGHVAP QNTYLDTIIR KFEGQSRKFL IANAQMENCA IIYCNDGFCE LFGYSRVEVM
    61  QQPCTCDFLT GPNTPSSAVS RLAQALLGAE ECKVDILYYR KDASSFRCLV DVVPVKNEDG
   121  AVIMFILNFE DLAQLLAKCS SRSLSQRLLS QSFLGSEGSH GRPGGPGPGT GRGKYRTISQ
   181  IPQFTLNFVE FNLEKHRSSS TTEIEIIAPH KVVERTQNVT EKVTQVLSLG ADVLPEYKLQ
   241  APRIHRWTIL HYSPFKAVWD WLILLLVIYT AVFTPYSAAF LLSDQDESRR GACSYTCSPL
   301  TVVDLIVDIM FVVDIVINFR TTYVNTNDEV VSHPRRIAVH YFKGWFLIDM VAAIPFDLLI
   361  FRTGSDETTT LIGLLKTARL LRLVRVARKL DRYSEYGAAV LFLLMCTFAL IAHWLACIWY
   421  AIGNVERPYL EHKIGWLDSL GVQLGKRYNG SDPASGPSVQ DKYVTALYFT FSSLTSVGFG
   481  NVSPNTNSEK VFSICVMLIG SLMYASIFGN VSAIIQRLYS GTARYHTQML RVKEFIRFHQ
   541  IPNPLRQRLE EYFQHAWSYT NGIDMNAVLK GFPECLQADI CLHLHRALLQ HCPAFSGAGK
   601  GCLRALAVKF KTTHAPPGDT LVHLGDVLST LYFISRGSIE ILRDDVVVAI LGKNDIFGEP
   661  VSLHAQPGKS SADVRALTYC DLHKIQRADL LEVLDMYPAF AESFWSKLEV TFNLRDAAGG
   721  LHSSPRQAPG SQDHQGFFLS DNQSDAAPPL SISDASGLWP ELLQEMPPRH SPQSPQEDPD
   781  CWPLKLGSRL EQLQAQMNRL ESRVSSDLSR ILQLLQKPMP QGHASYILEA PASNDLALVP
   841  IASETTSPGP RLPQGFLPPA QTPSYGDLDD CSPKHRNSSP RMPHLAVATD KTLAPSSEQE
   901  QPEGLWPPLA SPLHPLEVQG LICGPCFSSL PEHLGSVPKQ LDFQRHGSDP GFAGSWGH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNH6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
6.7 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 6.7 nTPM
  • pituitary gland: 5.3 nTPM
  • small intestine: 4.5 nTPM
  • retina: 4.1 nTPM
  • prostate: 3.9 nTPM
  • duodenum: 2.1 nTPM

Single-cell type

  • proximal tubule cells: 95 nCPM
  • enterocytes: 55 nCPM
  • retinal bipolar cells: 48 nCPM
  • neuroendocrine cells: 42 nCPM
  • pancreatic islet cells: 28 nCPM
  • prostatic glandular cells: 27 nCPM

Immune cell

  • basophil: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • pons: 5.2 nTPM
  • medulla oblongata: 5.1 nTPM
  • hypothalamus: 5 nTPM
  • thalamus: 5 nTPM
  • midbrain: 4.9 nTPM
  • cerebral cortex: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.4
gnomAD pLI
0
gnomAD missense Z
-0.21
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNH6 as an antibody target. Whether an autoantibody or antibody against KCNH6 could matter depends on whether native KCNH6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNH6 is annotated at the cell surface, where native KCNH6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNH6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNH6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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