KCNE5

Protein identityUniProt · HPA

UniProt accession

Q9UJ90

Gene

KCNE5

Ensembl

ENSG00000176076

Chromosome

X

Canonical length

142 aa

Protein class

Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of a family of single pass transmembrane domain proteins that function as ancillary subunits to voltage-gated potassium channels. Members of this family affect diverse processes in potassium channel regulation, including ion selectivity, voltage dependence, and anterograde recycling from the plasma membrane. Variants of this gene are associated with idiopathic ventricular fibrillation and Brugada syndrome. [provided by RefSeq, Nov 2016]

Canonical amino-acid sequenceUniProt

142 residues, UniProt reviewed canonical sequence.

>Q9UJ90|KCNE5
     1  MNCSESQRLR TLLSRLLLEL HHRGNASGLG AGPRPSMGMG VVPDPFVGRE VTSAKGDDAY
    61  LYILLIMIFY ACLAGGLILA YTRSRKLVEA KDEPSQACAE HEWAPGGALT ADAEAAAGSQ
   121  AEGRRQLASE GLPALAQGAE RV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNE5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.64

Highest tissue expression

17 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KCNE5.

Disease | AllUniProt

Conditions KCNE5 is implicated in, by any mechanism.

• AMME complex (ATS-MR) MIM:300194

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.83

gnomAD pLI

0.12

DepMap mean gene effect

0.13

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• atrial cardiac muscle cell action potential
• cardiac muscle contraction
• membrane repolarization during action potential
• membrane repolarization during ventricular cardiac muscle cell action potential
• negative regulation of potassium ion export across plasma membrane
• negative regulation of potassium ion transmembrane transport
• positive regulation of potassium ion transmembrane transport
• potassium ion export across plasma membrane
• regulation of atrial cardiac muscle cell membrane repolarization
• regulation of heart contraction
• regulation of heart rate by cardiac conduction
• regulation of membrane repolarization
• regulation of potassium ion transmembrane transport
• regulation of ventricular cardiac muscle cell membrane repolarization
• ventricular cardiac muscle cell action potential

Molecular functions

• potassium channel regulator activity
• transmembrane transporter binding
• voltage-gated potassium channel activity

Cellular components

• plasma membrane
• voltage-gated potassium channel complex

Protein domainsUniProt · Pfam · InterPro

• Potassium channel, voltage-dependent, beta subunit, KCNE

KeywordsUniProt

• Alport syndrome
• Deafness
• Elliptocytosis
• Glycoprotein
• Hereditary hemolytic anemia
• Intellectual disability
• Membrane
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of KCNE5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• KCNQ1