KCNE4

Protein identityUniProt · HPA

UniProt accession

Q8WWG9

Gene

KCNE4

Ensembl

ENSG00000152049

Chromosome

2

Canonical length

221 aa

Protein class

Predicted membrane proteins

Subcellular location

Nuclear bodies,Microtubules

OverviewNCBI Gene

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

221 residues, UniProt reviewed canonical sequence.

>Q8WWG9|KCNE4
     1  MHFLTIYPNC SSGVVRAQSR TEQKNPLGLD DLGIQNLGQT VSLAPAVEAA SMLKMEPLNS
    61  THPGTAASSS PLESRAAGGG SGNGNEYFYI LVVMSFYGIF LIGIMLGYMK SKRREKKSSL
   121  LLLYKDEERL WGEAMKPLPV VSGLRSVQVP LMLNMLQESV APALSCTLCS MEGDSVSSES
   181  SSPDVHLTIQ EEGADDELEE TSETPLNESS EGSSENIHQN S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNE4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.67

Highest tissue expression

40 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KCNE4.

Disease | ImmuneIEDB

Conditions an epitope on KCNE4 was assayed in.

• lung adenocarcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.36

gnomAD pLI

0.24

gnomAD missense Z

0.34

DepMap mean gene effect

0.18

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• membrane repolarization during action potential
• membrane repolarization during ventricular cardiac muscle cell action potential
• potassium ion export across plasma membrane
• regulation of heart rate by cardiac conduction
• regulation of ventricular cardiac muscle cell membrane repolarization
• ventricular cardiac muscle cell action potential

Molecular functions

• potassium channel inhibitor activity
• potassium channel regulator activity
• transmembrane transporter binding
• voltage-gated potassium channel activity

Cellular components

• apical plasma membrane
• voltage-gated potassium channel complex

Protein domainsUniProt · Pfam · InterPro

• Potassium channel, voltage-dependent, beta subunit, KCNE
• Slow voltage-gated potassium channel

KeywordsUniProt

• Alternative initiation
• Glycoprotein
• Ion channel
• Ion transport
• Membrane
• Potassium
• Potassium channel
• Potassium transport
• Transmembrane
• Transmembrane helix
• Transport
• Voltage-gated channel

InteractionsUniProt · HPA

Protein binding partners of KCNE4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• KCNQ1