Seroatlas · Human Serome Atlas

KCNAB3

Voltage-gated potassium channel subunit beta-3

Also known as: AKR6A9, KCAB3_HUMAN, KCNA3B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43448
Gene
KCNAB3
Ensembl
ENSG00000170049
Chromosome
17
Canonical length
404 aa
Protein class
Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. The encoded protein is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. The encoded protein forms a heterodimer with the potassium voltage-gated channel, shaker-related subfamily, member 5 gene product and regulates the activity of the alpha subunit. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

404 residues, UniProt reviewed canonical sequence.

>O43448|KCNAB3
     1  MQVSIACTEQ NLRSRSSEDR LCGPRPGPGG GNGGPAGGGH GNPPGGGGSG PKARAALVPR
    61  PPAPAGALRE STGRGTGMKY RNLGKSGLRV SCLGLGTWVT FGSQISDETA EDVLTVAYEH
   121  GVNLFDTAEV YAAGKAERTL GNILKSKGWR RSSYVITTKI FWGGQAETER GLSRKHIIEG
   181  LRGSLERLQL GYVDIVFANR SDPNCPMEEI VRAMTYVINQ GLALYWGTSR WGAAEIMEAY
   241  SMARQFNLIP PVCEQAEHHL FQREKVEMQL PELYHKIGVG SVTWYPLACG LITSKYDGRV
   301  PDTCRASIKG YQWLKDKVQS EDGKKQQAKV MDLLPVAHQL GCTVAQLAIA WCLRSEGVSS
   361  VLLGVSSAEQ LIEHLGALQV LSQLTPQTVM EIDGLLGNKP HSKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNAB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 34 nTPM
  • endometrium: 14 nTPM
  • retina: 10 nTPM
  • cerebral cortex: 9.6 nTPM
  • cervix: 6.6 nTPM
  • fallopian tube: 5.1 nTPM

Single-cell type

  • retinal horizontal cells: 52 nCPM
  • retinal amacrine cells: 49 nCPM
  • decidual stromal cells: 29 nCPM
  • brain inhibitory neurons: 21 nCPM
  • endometrial stromal cells: 13 nCPM
  • oligodendrocyte progenitor cells: 12 nCPM

Immune cell

  • plasmacytoid DC: 0.2 nTPM
  • myeloid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • cerebellum: 18 nTPM
  • cerebral cortex: 14 nTPM
  • midbrain: 14 nTPM
  • thalamus: 8.4 nTPM
  • white matter: 6.9 nTPM
  • pons: 6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.2
gnomAD pLI
0
gnomAD missense Z
0.01
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KCNAB3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNAB3 as an antibody target. Whether an autoantibody or antibody against KCNAB3 could matter depends on whether native KCNAB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNAB3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KCNAB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNAB3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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