Seroatlas · Human Serome Atlas

KANSL1L

KAT8 regulatory NSL complex subunit 1-like protein

Also known as: C2orf67, FLJ23861, FLJ32349, KAL1L_HUMAN, KIAA1267L, MSL1v2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0AUZ9
Gene: KANSL1L
Ensembl: ENSG00000144445
Chromosome: 2
Canonical length: 987 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable histone acetyltransferase binding activity. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of NSL complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

987 residues, UniProt reviewed canonical sequence.

>A0AUZ9|KANSL1L
     1  MTPALREATA KGISFSSLPS TMESDKMLYM ESPRTVDEKL KGDTFSQMLG FPTPEPTLNT
    61  NFVNLKHFGS PQSSKHYQTV FLMRSNSTLN KHNENYKQKK LGEPSCNKLK NILYNGSNIQ
   121  LSKICLSHSE EFIKKEPLSD TTSQCMKDVQ IILDSNITKD TNVDKVQLQN CKWYQENALL
   181  DKVTDAEIKK GLLHCTQKKI VPGHSNVPVS SSAAEKEEEV HARLLHCVSK QKILLSQARR
   241  TQKHLQMLLA KHVVKHYGQQ MKLSMKHQLP KMKTFHEPTT ILGNSLPKCT EIKPEVNTLT
   301  AENKLWDDAK NGFARCTAAE IQRFAFSATG LLSHVEEGLD SDATDSSSDD DLDEYTLRKN
   361  VAVNCSTEWK WLVDRARVGS RWTWLQAQIS DLECKIQQLT DIHRQIRASK GIVVLEECQL
   421  PKDILKKQMQ FADQAASLNI LGNPQVPQEC QDPVPEQDFE MSPSSPTLLL RNIEKQSAQL
   481  TEIINSLIAP LNLSPTSSPL SSKSCSHKCL ANGIYRSASE NLDELSSSSS WLLNQKHSKK
   541  KRKDRTRLKS SSLTFMSTSA RTRPLQSFHK RKLYRLSPTF YWTPQTLPSK ETAFLNTTQM
   601  PCLQSASTWS SYEHNSESYL LREHVSELDS SFHSVLSLPS DVPLHFHFET LLKKTEIKGN
   661  LAENKFVDEY IISPSPVHST LNQWRNGYSP ICKPQIRSES SAQLLQGRKK RHLSETALGE
   721  RTKLEESDFQ HTESGSHSNF TAVSNVNVLS RIQNSSRNTA RRRLRSESSY DIDNIVIPMS
   781  LVAPAKLEKL QYKEILTPSW RMVVLQPLDE YNLGKEEIED LSDEVFSLRH KKYEEREQAR
   841  WSLWEQSKWH RRNSRAYSKN VEGQDLLLKE YPNNFSSSQQ CAAASPPGLP SENQDLCAYG
   901  LPSLNQSQET KSLWWERRAF PLKGEDMAAL LCQDEKKDQV ERSSTAFHGE IFGTSVPENG
   961  HHPKKQSDGM EEYKTFGLGL TNVKKNR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KANSL1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 187 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 187 nTPM
thymus: 25 nTPM
blood vessel: 24 nTPM
testis: 24 nTPM
kidney: 21 nTPM
ovary: 21 nTPM

Single-cell type

myonuclei: 457 nCPM
proximal tubule cells: 455 nCPM
renal connecting tubule cells: 416 nCPM
renal collecting duct intercalated cells: 409 nCPM
bergmann glia: 407 nCPM
ependymal cells: 377 nCPM

Immune cell

NK-cell: 0.6 nTPM
eosinophil: 0.5 nTPM
intermediate monocyte: 0.4 nTPM
myeloid DC: 0.4 nTPM
neutrophil: 0.4 nTPM
classical monocyte: 0.3 nTPM

Brain region

white matter: 48 nTPM
cerebellum: 42 nTPM
basal ganglia: 40 nTPM
midbrain: 40 nTPM
medulla oblongata: 38 nTPM
pons: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.35
gnomAD pLI: 0.66
gnomAD missense Z: 0.25
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

histone acetyltransferase binding

Cellular components

NSL complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KANSL1L as an antibody target. Whether an autoantibody or antibody against KANSL1L could matter depends on whether native KANSL1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KANSL1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KANSL1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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