Seroatlas · Human Serome Atlas

KANK4

KN motif and ankyrin repeat domain-containing protein 4

Also known as: ANKRD38, KANK4_HUMAN, KIAA0172

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T7N3
Gene: KANK4
Ensembl: ENSG00000132854
Chromosome: 1
Canonical length: 995 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubules,Cytosol

OverviewNCBI Gene

Predicted to be involved in negative regulation of actin filament polymerization. Located in cytosol and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

995 residues, UniProt reviewed canonical sequence.

>Q5T7N3|KANK4
     1  MEKTDAKDQS SQGDEEKDPP KSHPYSVETP YGFHLDLDFL KYVDDIEKGN TIKRIPIHRR
    61  AKQAKFSTLP RNFSLPDSGA RPPAAPPLQN WSPVVPREAS LGTQEQNQSP PLGNAPQAST
   121  SRSEVSYHRK ALLAEATRQL EAAEPEDAEL TFGSGRPQLL RASSMPATLL HSRASEEPGL
   181  SLGPPAPPAL PPLQGEGSVC DGTFEPAEGL AGFHSSSPRA STRIPELVQE GAEPPEGVVK
   241  VPNHLPLPGP PFSFQNVLVV LEDKEDEHNA REAEVLFTPG SPTPSPPPLP SPIPENELLL
   301  EEIELNISEI PPPPPVEVDM RSIGIRVTEE SLGLARVDPG SISSLKQQVS ALEGELSGRT
   361  EELAQVRTAL QQQEEEIKAR EQRIRELEFT VAQLEGQFHQ ENAKDTQGQT DVMVNTDPVH
   421  GLLTRESCDK GIEVNLLGSM ESESWGHRGE ENGLLWGPDG HKQGNQSPAE RVLLPQLSLP
   481  QGPEQVLTSS VHSFLSTELR IEEAGTEQEG GPQGGTRGAG GFLWGSDRKT PPAGREETSS
   541  NLPGKEHPGR PPSSPTDATI GQYVKKIQEL LQEQWNCLEH GYPELASAIK QPASKLSSIQ
   601  SQLLSSLNLL LSAYSAQAHP PKEPPASSSS PPVEISPSTS LKSIMKKKDY GFRAGGNGTK
   661  KNLQFVGVNG GYETTSSEET SGEDSTPEDL SDSEAEKKCD GPDHKHVKDA HLTCEAGQGI
   721  PEGTCHAAQE SGPGEEVPHS KAERYKPSEE FLNACRALSQ HLPETGTTTD QLLRQSLNTI
   781  SQEWFRVSSR KSSSPAVVAS YLHEVQPHSP HFLKLLVNLA DHNGNTALHY SVSHSNFSIV
   841  KLLLETGVCN VDHQNKAGYT AVMITPLASA ETNEDMAVVW KLLREGNVNI QATQGGQTAL
   901  MLGVSHDRED MVQALLSCQA DVNLQDHDGS SALMVACHHG NVDLVRLLLA HPACDSSLTD
   961  KAGRTALSIA LKSPTHMEIA GLLRAHAEQG RSLGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KANK4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

pancreas: 13 nTPM
adipose tissue: 10 nTPM
placenta: 10 nTPM
spinal cord: 9.2 nTPM
salivary gland: 8 nTPM
midbrain: 7.4 nTPM

Single-cell type

cytotrophoblasts: 198 nCPM
adipocytes: 109 nCPM
lacrimal acinar cells: 107 nCPM
extravillous trophoblasts: 104 nCPM
migrating cytotrophoblasts: 92 nCPM
schwann cells: 67 nCPM

Immune cell

basophil: 0.2 nTPM
neutrophil: 0.2 nTPM
eosinophil: 0.1 nTPM
naive B-cell: 0.1 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM

Brain region

pons: 48 nTPM
midbrain: 31 nTPM
medulla oblongata: 28 nTPM
cerebellum: 22 nTPM
white matter: 19 nTPM
thalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0
gnomAD missense Z: 0.2
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of actin filament polymerization

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KANK4 as an antibody target. Whether an autoantibody or antibody against KANK4 could matter depends on whether native KANK4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KANK4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KANK4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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