Seroatlas · Human Serome Atlas

KANK3

KN motif and ankyrin repeat domain-containing protein 3

Also known as: ANKRD47, FLJ46061, KANK3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NY19
Gene: KANK3
Ensembl: ENSG00000186994
Chromosome: 19
Canonical length: 821 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Predicted to be involved in negative regulation of actin filament polymerization. Predicted to be active in cytoplasm and cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

821 residues, UniProt reviewed canonical sequence.

>Q6NY19|KANK3
     1  MAKFALNQNL PDLGGPRLCP VPAAGGARSP SSPYSVETPY GFHLDLDFLK YIEELERGPA
    61  ARRAPGPPTS RRPRAPRPGL AGARSPGAWT SSESLASDDG GAPGILSQGA PSGLLMQPLS
   121  PRAPVRNPRV EHTLRETSRR LELAQTHERA PSPGRGVPRS PRGSGRSSPA PNLAPASPGP
   181  AQLQLVREQM AAALRRLREL EDQARTLPEL QEQVRALRAE KARLLAGRAQ PEPDGEAETR
   241  PDKLAQLRRL TERLATSERG GRARASPRAD SPDGLAAGRS EGALQVLDGE VGSLDGTPQT
   301  REVAAEAVPE TREAGAQAVP ETREAGVEAA PETVEADAWV TEALLGLPAA AERELELLRA
   361  SLEHQRGVSE LLRGRLRELE EAREAAEEAA AGARAQLREA TTQTPWSCAE KAAQTESPAE
   421  APSLTQESSP GSMDGDRAVA PAGILKSIMK KRDGTPGAQP SSGPKSLQFV GVLNGEYESS
   481  SSEDASDSDG DSENGGAEPP GSSSGSGDDS GGGSDSGTPG PPSGGDIRDP EPEAEAEPQQ
   541  VAQGRCELSP RLREACVALQ RQLSRPRGVA SDGGAVRLVA QEWFRVSSQR RSQAEPVARM
   601  LEGVRRLGPE LLAHVVNLAD GNGNTALHYS VSHGNLAIAS LLLDTGACEV NRQNRAGYSA
   661  LMLAALTSVR QEEEDMAVVQ RLFCMGDVNA KASQTGQTAL MLAISHGRQD MVATLLACGA
   721  DVNAQDADGA TALMCASEYG RLDTVRLLLT QPGCDPAILD NEGTSALAIA LEAEQDEVAA
   781  LLHAHLSSGQ PDTQSESPPG SQTATPGEGE CGDNGENPQV Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KANK3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

spleen: 31 nTPM
heart muscle: 31 nTPM
lung: 30 nTPM
breast: 24 nTPM
adipose tissue: 23 nTPM
kidney: 17 nTPM

Single-cell type

lymphatic endothelial cells: 245 nCPM
vascular endothelial cells: 152 nCPM
epicardial cells: 39 nCPM
vascular smooth muscle cells: 34 nCPM
pericytes: 32 nCPM
retinal pigment epithelial cells: 17 nCPM

Immune cell

NK-cell: 1.2 nTPM
gdT-cell: 1 nTPM
MAIT T-cell: 0.5 nTPM
memory CD4 T-cell: 0.5 nTPM
T-reg: 0.4 nTPM
naive CD8 T-cell: 0.3 nTPM

Brain region

thalamus: 20 nTPM
medulla oblongata: 18 nTPM
amygdala: 17 nTPM
midbrain: 16 nTPM
pons: 16 nTPM
basal ganglia: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: 0.95
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of actin filament polymerization

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KANK3 as an antibody target. Whether an autoantibody or antibody against KANK3 could matter depends on whether native KANK3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KANK3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KANK3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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