Seroatlas · Human Serome Atlas

KAAG1

Kidney-associated antigen 1

Also known as: KAAG1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UBP8
Gene: KAAG1
Canonical length: 84 aa

OverviewNCBI Gene

No narrative summary is available for KAAG1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

84 residues, UniProt reviewed canonical sequence.

>Q9UBP8|KAAG1
     1  MDDDAAPRVE GVPVAVHKHA LHDGLRQVAG PGAAAAHLPR WPPPQLAASR REAPPLSQRP
    61  HRTQGAGSPP ETNEKLTNPQ VKEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KAAG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.72

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KAAG1.

Disease | ImmuneIEDB

Conditions an epitope on KAAG1 was assayed in.

melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0.29
gnomAD missense Z: 0.74

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

immune response

Protein domainsUniProt · Pfam · InterPro

Kidney-associated antigen 1
Kidney-associated antigen 1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KAAG1 as an antibody target. Whether an autoantibody or antibody against KAAG1 could matter depends on whether native KAAG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KAAG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KAAG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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