Seroatlas · Human Serome Atlas

JSRP1

Junctional sarcoplasmic reticulum protein 1

Also known as: FLJ32416, JP-45, JSPR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MG2
Gene: JSRP1
Ensembl: ENSG00000167476
Chromosome: 19
Canonical length: 331 aa
Protein class: Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

The protein encoded by this gene is involved in excitation-contraction coupling at the sarcoplasmic reticulum. The encoded protein can interact with CACNA1S, CACNB1, and calsequestrin to help regulate calcium influx and efflux in skeletal muscle. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

331 residues, UniProt reviewed canonical sequence.

>Q96MG2|JSRP1
     1  MSMTTRAWEE LDGGLGSCQA LEDHSALAET QEDRASATPR LADSGSVPHD SQVAEGPSVD
    61  TRPKKMEKEP AARGTPGTGK ERLKAGASPR SVPARKKAQT APPLQPPPPP PALSEELPWG
   121  DLSLNKCLVL ASLVALLGSA FQLCRDAVPG EAALQARVPE PWVPPSSAPR EPSSPLPKFE
   181  AQAPPSAPPA PRAEAEVRPK IPGSREAAEN DEEEPGEATG EAVREDRVTL ADRGPKERPR
   241  REGKPRKEKP RKEERPKKER PRKEERPRAA REPREALPQR WESREGGHRP WARDSRDAEP
   301  RKKQAWVSPR RPDEEQRPGS RQKLRAGKGR D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JSRP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 326 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 326 nTPM
tongue: 17 nTPM
salivary gland: 8.6 nTPM
spleen: 5.3 nTPM
duodenum: 2.7 nTPM
testis: 1.8 nTPM

Single-cell type

plasma cells: 283 nCPM
cardiomyocytes: 210 nCPM
thymic myoid cells: 131 nCPM
myosatellite cells: 113 nCPM
epicardial cells: 100 nCPM
platelets: 95 nCPM

Immune cell

naive B-cell: 2.7 nTPM
MAIT T-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

hypothalamus: 0.8 nTPM
amygdala: 0.5 nTPM
basal ganglia: 0.5 nTPM
cerebellum: 0.5 nTPM
cerebral cortex: 0.4 nTPM
hippocampal formation: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: 0.15
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

skeletal muscle contraction

Cellular components

Protein domainsUniProt · Pfam · InterPro

Junctional sarcoplasmic reticulum protein 1
Junctional sarcoplasmic reticulum protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of JSRP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads JSRP1 as an antibody target. Whether an autoantibody or antibody against JSRP1 could matter depends on whether native JSRP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

JSRP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label JSRP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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