Seroatlas · Human Serome Atlas

JOSD1

Josephin-1

Also known as: JOS1_HUMAN, KIAA0063

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15040
Gene: JOSD1
Ensembl: ENSG00000100221
Chromosome: 22
Canonical length: 202 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within several processes, including endocytosis; membrane biogenesis; and protein deubiquitination. Located in membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

202 residues, UniProt reviewed canonical sequence.

>Q15040|JOSD1
     1  MSCVPWKGDK AKSESLELPQ AAPPQIYHEK QRRELCALHA LNNVFQDSNA FTRDTLQEIF
    61  QRLSPNTMVT PHKKSMLGNG NYDVNVIMAA LQTKGYEAVW WDKRRDVGVI ALTNVMGFIM
   121  NLPSSLCWGP LKLPLKRQHW ICVREVGGAY YNLDSKLKMP EWIGGESELR KFLKHHLRGK
   181  NCELLLVVPE EVEAHQSWRT DV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JOSD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 85 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 85 nTPM
ovary: 45 nTPM
colon: 39 nTPM
rectum: 36 nTPM
blood vessel: 34 nTPM
small intestine: 34 nTPM

Single-cell type

neutrophils: 402 nCPM
endometrial glandular cells: 173 nCPM
urothelial cells: 147 nCPM
innate lymphoid cells: 140 nCPM
monocytes: 135 nCPM
ocular epithelial cells: 133 nCPM

Immune cell

naive CD8 T-cell: 3.6 nTPM
neutrophil: 3.6 nTPM
memory CD8 T-cell: 3.4 nTPM
T-reg: 3.2 nTPM
intermediate monocyte: 2.8 nTPM
gdT-cell: 2.6 nTPM

Brain region

cerebral cortex: 45 nTPM
white matter: 42 nTPM
basal ganglia: 40 nTPM
hippocampal formation: 38 nTPM
amygdala: 37 nTPM
cerebellum: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0.04
gnomAD missense Z: 1.81
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cysteine-type deubiquitinase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of JOSD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KRT31

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads JOSD1 as an antibody target. Whether an autoantibody or antibody against JOSD1 could matter depends on whether native JOSD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

JOSD1 is annotated at the cell surface, where native JOSD1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label JOSD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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