Seroatlas · Human Serome Atlas

JMJD8

JmjC domain-containing protein 8

Also known as: C16orf20, JMJD8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96S16
Gene: JMJD8
Ensembl: ENSG00000161999
Chromosome: 16
Canonical length: 264 aa
Protein class: Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to enable cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of canonical NF-kappaB signal transduction; positive regulation of sprouting angiogenesis; and regulation of pyruvate kinase activity. Located in endoplasmic reticulum lumen and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

264 residues, UniProt reviewed canonical sequence.

>Q96S16|JMJD8
     1  MAPASRLLAL WALAAVALPG SGAEGDGGWR PGGPGAVAEE ERCTVERRAD LTYAEFVQQY
    61  AFVRPVILQG LTDNSRFRAL CSRDRLLASF GDRVVRLSTA NTYSYHKVDL PFQEYVEQLL
   121  HPQDPTSLGN DTLYFFGDNN FTEWASLFRH YSPPPFGLLG TAPAYSFGIA GAGSGVPFHW
   181  HGPGYSEVIY GRKRWFLYPP EKTPEFHPNK TTLAWLRDTY PALPPSARPL ECTIRAGEVL
   241  YFPDRWWHAT LNLDTSVFIS TFLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JMJD8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 58 nTPM
blood vessel: 58 nTPM
liver: 55 nTPM
kidney: 51 nTPM
adrenal gland: 50 nTPM
pancreas: 46 nTPM

Single-cell type

esophageal apical cells: 132 nCPM
late spermatids: 87 nCPM
epididymal principal cells: 85 nCPM
breast lactating cells: 62 nCPM
smooth muscle cells: 58 nCPM
breast myoepithelial cells: 56 nCPM

Immune cell

myeloid DC: 7.3 nTPM
T-reg: 6.7 nTPM
MAIT T-cell: 6.5 nTPM
classical monocyte: 6.3 nTPM
memory CD4 T-cell: 5.7 nTPM
intermediate monocyte: 5.2 nTPM

Brain region

choroid plexus: 41 nTPM
medulla oblongata: 22 nTPM
thalamus: 21 nTPM
spinal cord: 17 nTPM
midbrain: 16 nTPM
hippocampal formation: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.81
gnomAD pLI: 0
gnomAD missense Z: -1.92
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of canonical NF-kappaB signal transduction
positive regulation of sprouting angiogenesis
regulation of glycolytic process
regulation of pyruvate kinase activity

Molecular functions

cis-regulatory region sequence-specific DNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of JMJD8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads JMJD8 as an antibody target. Whether an autoantibody or antibody against JMJD8 could matter depends on whether native JMJD8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

JMJD8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label JMJD8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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