Seroatlas · Human Serome Atlas

JHY

Jhy protein homolog

Also known as: C11orf63, FLJ23554, JHY_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6NUN7
Gene
JHY
Ensembl
ENSG00000109944
Chromosome
11
Canonical length
778 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Predicted to be involved in axoneme assembly and brain development. Predicted to act upstream of or within several processes, including cerebrospinal fluid circulation; motile cilium assembly; and regulation of establishment of planar polarity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

778 residues, UniProt reviewed canonical sequence.

>Q6NUN7|JHY
     1  MSKRKLIPKL SIQSPVLHTN LNVQSTHPPL KKEDLHRISK DSLESDSESL TQEIMCHSEF
    61  DDRIRGNGME PDSLDEEESP RWGSLHEMEE EASGKAAQMA REQNHHTWDQ GANNRQQPIE
   121  DKYSDLRYDP NWKSKKEEGQ LLSVEALPES TDSSLENLPL APLYPSQETS MELSGGKGEQ
   181  KESPQSAASL LGSEFLSPNY EHGARRSKPF SELSDSDLEE KSSSLSPYVK SSSSHNEVFL
   241  PGSRGPRRRK SKQHFVEKNK LTLGLPTPKT DSYLQLHNKK RGESHPEQIS YPVRVTDKTS
   301  IQNAKEMENA AIDPEDKWHQ RAQQLKNYQE HWSQYESTKS SNVPRGQPSD MVNDHQPSRR
   361  PAKLKIRKQC KHQNGLKSST TEEVTASQGN QNNPPRQQQN QNKPLDTSTK PESIVIMHAS
   421  NNDVQASRAL RSHNLKETSN TFAPPKQAFD KVLSKNSTGC DSGLNVNKER GHKDQEEKRF
   481  SYQQLHTLSD MDLNNLNELS KRHVLLSQKG SQFVYHINTH GSTKNKKQLK QPYTETKYRN
   541  LEMLWKFHSS SDSQTVRASP DSWLTQIMEQ HQQALVQLTD VQPSEGALSS VTLPPILSRV
   601  ESESQLSSER SQRNQVKISR SNSEGYLFQL EKGKKHKKRS SSKNTKLKGY QKRDVKLGGL
   661  GPDFESIRDK TQKLIQQKEY AKQVKEYNMK TLSILSKPQT EKTQKKSAIP RQKALEYAKT
   721  IPKPKPSNLT HQASKEQKNP TYAGKEESLP EISLLEILQN RHEREKQAVA AFKVLHIV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JHY can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • testis: 33 nTPM
  • choroid plexus: 16 nTPM
  • kidney: 7.3 nTPM
  • fallopian tube: 7 nTPM
  • adipose tissue: 5.6 nTPM
  • parathyroid gland: 5.3 nTPM

Single-cell type

  • choroid plexus epithelial cells: 215 nCPM
  • ependymal cells: 164 nCPM
  • respiratory ciliated cells: 135 nCPM
  • late primary spermatocytes: 132 nCPM
  • fallopian tube ciliated cells: 110 nCPM
  • endometrial ciliated cells: 93 nCPM

Immune cell

  • myeloid DC: 2.4 nTPM
  • NK-cell: 2.4 nTPM
  • MAIT T-cell: 1.8 nTPM
  • memory CD8 T-cell: 1.7 nTPM
  • gdT-cell: 1.3 nTPM
  • memory CD4 T-cell: 1.3 nTPM

Brain region

  • choroid plexus: 43 nTPM
  • midbrain: 17 nTPM
  • medulla oblongata: 15 nTPM
  • spinal cord: 14 nTPM
  • hypothalamus: 14 nTPM
  • white matter: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.92
gnomAD pLI
0
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Jhy protein
  • Jhy protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads JHY as an antibody target. Whether an autoantibody or antibody against JHY could matter depends on whether native JHY is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

JHY is annotated as secreted, so native JHY circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label JHY as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/JHY. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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