Seroatlas · Human Serome Atlas

JCAD

Junctional cadherin 5-associated protein

Also known as: JCAD_HUMAN, KIAA1462

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P266
Gene: JCAD
Ensembl: ENSG00000165757
Chromosome: 10
Canonical length: 1359 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cell Junctions

OverviewNCBI Gene

This gene encodes an endothelial cell-to-cell junction protein. Naturally occurring mutations in this gene are associated with coronary artery disease, late onset alzheimer disease, and emphysema distribution. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

1359 residues, UniProt reviewed canonical sequence.

>Q9P266|JCAD
     1  MYSVEDLLIS HGYKLSRDPP ASREDNPKGR QAARTGTRAG QGLQNGHEDG PAALAHRKTS
    61  AGKGHVSDSE SRRSTPRGHG EPQSTSASRT SEAGFCNQPP SAWSSHPPTG NDQAYRRRGR
   121  QEARSQKPRE HENLEARGMA QAHSLPVHVR EGPWEVGGRS EHVMKKPVWE EELRMSGPAK
   181  WQNVSLESWN QPRKLGRQMS DGDGERLFQD LYPFIQGEHV LNSQNKGKSR SLPRVLSPES
   241  LSCTEIPIPL NERHSPKMPP YPPTCAPNLD STRNSEKSGC SAPFPRPKFG RPLKPPSYSS
   301  HQQSRGGADS SDSQDSQQMD AYVPRHELCL SDPGLEPPVY VPPPSYRSPP QNIPNPYLED
   361  TVPINVCGGH SQQQSPTEKA GASGQPPSGP PGTGNEYGVS PRLPQGLPAH PRPVTAYDGF
   421  VQYIPFDDPR LRHFKLAQPQ GFCEDIKLDD KSYNSSPVTA QEPAHGGMQP DGAIWNPQSL
   481  IPPSGDERGL VLADSSPRWL WGQPPGDGEN SGLPNQRDRC VARGQWPDVR GSQHGHTGRQ
   541  VSSPYSQGES TCETQTKLKK FQTGTRTKKS SKKKMNETIF CLVSIPVKSE SHLPDRDMDN
   601  NDLKPSADQK NGSDKSPALQ EQSLLSMSST DLELQALTGS MGGRTEFQKQ DLGEPEEDRQ
   661  TNDLSFIHLT KHRELKHSGS WPGHRYRDQQ TQTSFSEEPQ SSQLLPGAKL GGPSRAALSP
   721  KCSDPAASEA QTHTAFPTGD HKQRPSARNL KGHRSLSPSS NSAFSRTSLS VDQAPTPKAG
   781  RSQPCVDVHG LGAHPGPKRE VVKGEPTGPC NSKQLFGQFL LKPVSRRPWD LISQLESFNK
   841  ELQEEEESSS SSSSSSSSSE ESEAEPQQEN RAHCRQEDVG FRGNSPEMRV EPQPRMWVPE
   901  SPVCRSGRGE SKSESWSEEL QPGHPRAWPP SPGRFRVEEG GGAPFCSADG STSAEKRHLE
   961  VSNGMDELAG SPFPVTRMSS RSSDAKPLPA SYPAEPREPQ ESPKITSAFS SVKPSEAVPR
  1021  KFDSGGERGA GLPLSLSNKN RGLSAPDLRS VGLTPGQEQG ASELEGSLGE ASTIEIPPGE
  1081  SLQARAARIL GIEVAVESLL PGIRRAGQNQ PAEPDASACT PESPQEELLS RPAPADVPRV
  1141  STDAFYGRRK CGWTKSPLFV GDRDSARRAP QAFEHSDVDG VVTSTDPVPE PEPSPLESKF
  1201  FEQKDVETKP PFRSTLFHFV ERTPSVAGSE KRLRSPSKVI ESLQEKLASP PRRADPDRLM
  1261  RMKEVSSVSR MRVLSFRNAD SQEDAEELKA TTRGQAGLPG GLVSPGSGDR AQRLGHSLSV
  1321  SKDSISREEK EHPAAQKEKS MDQDFWCPDS YDPSRVERV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JCAD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

colon: 33 nTPM
placenta: 32 nTPM
adipose tissue: 29 nTPM
lung: 23 nTPM
urinary bladder: 18 nTPM
heart muscle: 17 nTPM

Single-cell type

sertoli cells: 214 nCPM
vascular endothelial cells: 128 nCPM
retinal horizontal cells: 128 nCPM
medullary thymic epithelial cells: 108 nCPM
pancreatic duct cells: 88 nCPM
brain inhibitory neurons: 70 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 50 nTPM
thalamus: 34 nTPM
amygdala: 34 nTPM
cerebral cortex: 33 nTPM
medulla oblongata: 33 nTPM
pons: 27 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about JCAD.

Disease | ImmuneIEDB

Conditions an epitope on JCAD was assayed in.

narcolepsy B cell
multiple sclerosis B cell
peripheral nervous system disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Junctional cadherin 5-associated protein
Junctional protein associated with coronary artery disease

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of JCAD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CAMKV

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads JCAD as an antibody target. Whether an autoantibody or antibody against JCAD could matter depends on whether native JCAD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

JCAD is annotated at the cell surface, where native JCAD is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label JCAD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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