Seroatlas · Human Serome Atlas

JAZF1

Juxtaposed with another zinc finger protein 1

Also known as: DKFZp761K2222, JAZF1_HUMAN, TIP27, ZNF802

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86VZ6
Gene
JAZF1
Ensembl
ENSG00000153814
Chromosome
7
Canonical length
243 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center,Primary cilium tip,Cytosol

OverviewNCBI Gene

This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

243 residues, UniProt reviewed canonical sequence.

>Q86VZ6|JAZF1
     1  MTGIAAASFF SNTCRFGGCG LHFPTLADLI EHIEDNHIDT DPRVLEKQEL QQPTYVALSY
    61  INRFMTDAAR REQESLKKKI QPKLSLTLSS SVSRGNVSTP PRHSSGSLTP PVTPPITPSS
   121  SFRSSTPTGS EYDEEEVDYE ESDSDESWTT ESAISSEAIL SSMCMNGGEE KPFACPVPGC
   181  KKRYKNVNGI KYHAKNGHRT QIRVRKPFKC RCGKSYKTAQ GLRHHTINFH PPVSAEIIRK
   241  MQQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JAZF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
79 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 79 nTPM
  • cervix: 59 nTPM
  • endometrium: 38 nTPM
  • smooth muscle: 36 nTPM
  • seminal vesicle: 33 nTPM
  • blood vessel: 32 nTPM

Single-cell type

  • endometrial stromal cells: 1,267 nCPM
  • sertoli cells: 963 nCPM
  • microglia: 759 nCPM
  • pituitary stem cells: 743 nCPM
  • lactotrophs: 682 nCPM
  • choroid plexus epithelial cells: 650 nCPM

Immune cell

  • basophil: 26 nTPM
  • plasmacytoid DC: 14 nTPM
  • eosinophil: 7.1 nTPM
  • gdT-cell: 4.9 nTPM
  • NK-cell: 4.2 nTPM
  • classical monocyte: 4.1 nTPM

Brain region

  • hypothalamus: 46 nTPM
  • cerebral cortex: 37 nTPM
  • choroid plexus: 36 nTPM
  • basal ganglia: 35 nTPM
  • cerebellum: 33 nTPM
  • white matter: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.9
gnomAD missense Z
2.35
DepMap mean gene effect
-0.2
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of JAZF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads JAZF1 as an antibody target. Whether an autoantibody or antibody against JAZF1 could matter depends on whether native JAZF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

JAZF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label JAZF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/JAZF1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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