Seroatlas · Human Serome Atlas

JAKMIP3

Janus kinase and microtubule-interacting protein 3

Also known as: bA140A10.5, C10orf14, C10orf39, FLJ37857, JKIP3_HUMAN, KIAA4091, NECC2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VZ66
Gene: JAKMIP3
Ensembl: ENSG00000188385
Chromosome: 10
Canonical length: 844 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable kinase binding activity and microtubule binding activity. Predicted to be located in Golgi apparatus and membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

844 residues, UniProt reviewed canonical sequence.

>Q5VZ66|JAKMIP3
     1  MSKRGMSSRA KGDKAEALAA LQAANEDLRA KLTDIQIELQ QEKSKVSKVE REKNQELRQV
    61  REHEQHKTAV LLTELKTKLH EEKMKELQAV RETLLRQHEA ELLRVIKIKD NENQRLQALL
   121  SALRDGGPEK VKTVLLSEAK EEAKKGFEVE KVKMQQEISE LKGAKRQVEE ALTLVIQADK
   181  IKAAEIRSVY HLHQEEITRI KKECEREIRR LMEEIKFKDR AVFVLERELG VQAGHAQRLQ
   241  LQKEALDEQL SQVREADRHP GSPRRELPHA AGAGDASDHS GSPEQQLDEK DARRFQLKIA
   301  ELSAIIRKLE DRNALLSEER NELLKRVREA ESQYKPLLDK NKRLSRKNED LSHALRRMEN
   361  KLKFVTQENI EMRQRAGIIR RPSSLNDLDQ SQDEREVDFL KLQIVEQQNL IDELSKTLET
   421  AGYVKSVLER DKLLRFRKQR KKMAKLPKPV VVETFFGYDE EASLESDGSS VSYQTDRTDQ
   481  TPCTPDDDLE EGMAKEETEL RFRQLTMEYQ ALQRAYALLQ EQVGGTLDAE REVKTREQLQ
   541  AEVQRAQARI EDLEKALAEQ GQDMKWIEEK QALYRRNQEL VEKIKQMETE EARLRHEVQD
   601  ARDQNELLEF RILELEERER KSPAISFHHT PFVDGKSPLQ VYCEAEGVTD IVVAELMKKL
   661  DILGDNANLT NEEQVVVIQA RTVLTLAEKW LQQIEETEAA LQRKMVDLES EKELFSKQKG
   721  YLDEELDYRK QALDQANKHI LELEAMLYDA LQQEAGAKVA ELLSEEEREK LKVAVEQWKR
   781  QVMSELRERD AQILRERMEL LQLAQQRIKE LEERIEAQKR QIKELEEKFL FLFLFFSLAF
   841  ILWS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JAKMIP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 5.2 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 5.2 nTPM
cerebellum: 3.7 nTPM
pituitary gland: 3.7 nTPM
cerebral cortex: 3.5 nTPM
midbrain: 3.5 nTPM
hippocampal formation: 2.9 nTPM

Single-cell type

oligodendrocytes: 94 nCPM
lactotrophs: 67 nCPM
thyrotrophs: 55 nCPM
gonadotrophs: 50 nCPM
other brain neurons: 49 nCPM
oligodendrocyte progenitor cells: 49 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 58 nTPM
pons: 38 nTPM
medulla oblongata: 36 nTPM
thalamus: 31 nTPM
cerebral cortex: 28 nTPM
midbrain: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0.07
gnomAD missense Z: 1.32
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Golgi apparatus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads JAKMIP3 as an antibody target. Whether an autoantibody or antibody against JAKMIP3 could matter depends on whether native JAKMIP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

JAKMIP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label JAKMIP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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