Seroatlas · Human Serome Atlas

JAKMIP2

Janus kinase and microtubule-interacting protein 2

Also known as: JAMIP2, JKIP2_HUMAN, KIAA0555

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96AA8
Gene: JAKMIP2
Ensembl: ENSG00000176049
Chromosome: 5
Canonical length: 810 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

The protein encoded by this gene is reported to be a component of the Golgi matrix. It may act as a golgin protein by negatively regulating transit of secretory cargo and by acting as a structural scaffold of the Golgi. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

810 residues, UniProt reviewed canonical sequence.

>Q96AA8|JAKMIP2
     1  MSKKGRNKGE KPEALIVALQ AANEDLRTKL TDIQIELHQE KSKVSKLERE KTQEAKRIRE
    61  LEQRKHTVLV TELKAKLHEE KMKELQAVRE NLIKQHEQEM SRTVKVRDGE IQRLKSALCA
   121  LRDGSSDKVR TALTIEAREE ARKLFDTERL KLLQEIADLK TAKKQVDEAL SNMIQADKIK
   181  AGDLRSEHQS HQEAISKIKW ESERDIRRLM DEIKAKDRII FSLEKELETQ TGYVQKLQLQ
   241  KEALDEQLFL VKEAECNMSS PKREIPGRAG DGSEHCSSPD LRRNQKRIAE LNATIRKLED
   301  RNTLLGDERN ELLKRVRETE KQCKPLLERN KCLAKRNDEL MVSLQRMEEK LKAVTKENSE
   361  MREKITSHPP LKKLKSLNDL DQANEEQETE FLKLQVIEQQ NIIDELTRDR EKLIRRRKHR
   421  RSSKPIKRPV LDPFIGYDED SMDSETSSMA SFRTDRTPAT PDDDLDESLA AEESELRFRQ
   481  LTKEYQALQR AYALLQEQTG GIIDAEREAK AQEQLQAEVL RYKAKIEDLE ATLAQKGQDS
   541  HWVEDKQLFI KRNQELLEKI EKQEAENHRL QQELQDARDQ NELLEFRNLE LEERERRSPP
   601  FNLQIHPFSD GVSALQIYCM KEGVKDVNIP DLIKQLDILG DNGNLRNEEQ VAIIQASTVL
   661  SLAEKWIQQI EGAEAALHQK MMELESDMEQ FCKIKGYLEE ELDYRKQALD QAYMRIQELE
   721  ATLYNALQQE TVIKFGELLS EKQQEELRTA VEKLRRQMLR KSREYDCQIL QERMELLQQA
   781  HQRIRDLEDK TDIQKRQIKD LEEKSNRKHG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JAKMIP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 18 nTPM
cerebellum: 17 nTPM
midbrain: 14 nTPM
spinal cord: 14 nTPM
hippocampal formation: 13 nTPM
amygdala: 13 nTPM

Single-cell type

gonadotrophs: 458 nCPM
thyrotrophs: 399 nCPM
retinal horizontal cells: 395 nCPM
retinal ganglion cells: 367 nCPM
brain excitatory neurons: 351 nCPM
ependymal cells: 329 nCPM

Immune cell

gdT-cell: 7.3 nTPM
NK-cell: 7 nTPM
memory CD8 T-cell: 5.5 nTPM
MAIT T-cell: 5.3 nTPM
naive CD8 T-cell: 4.6 nTPM
memory CD4 T-cell: 2.8 nTPM

Brain region

cerebellum: 57 nTPM
white matter: 39 nTPM
cerebral cortex: 33 nTPM
hypothalamus: 32 nTPM
medulla oblongata: 32 nTPM
thalamus: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.18
gnomAD pLI: 1
gnomAD missense Z: 3.36
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Golgi apparatus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads JAKMIP2 as an antibody target. Whether an autoantibody or antibody against JAKMIP2 could matter depends on whether native JAKMIP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

JAKMIP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label JAKMIP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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