Seroatlas · Human Serome Atlas

JAKMIP1

Janus kinase and microtubule-interacting protein 1

Also known as: FLJ31564, Gababrbp, JAMIP1, JKIP1_HUMAN, MARLIN1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96N16
Gene: JAKMIP1
Ensembl: ENSG00000152969
Chromosome: 4
Canonical length: 626 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables GABA receptor binding activity and RNA binding activity. Involved in cognition. Located in membrane. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

626 residues, UniProt reviewed canonical sequence.

>Q96N16|JAKMIP1
     1  MSKKGRSKGE KPEMETDAVQ MANEELRAKL TSIQIEFQQE KSKVGKLRER LQEAKLEREQ
    61  EQRRHTAYIS ELKAKLHEEK TKELQALREG LIRQHEQEAA RTAKIKEGEL QRLQATLNVL
   121  RDGAADKVKT ALLTEAREEA RRAFDGERLR LQQEILELKA ARKQAEEALS NCMQADKTKA
   181  ADLRAAYQAH QDEVHRIKRE CERDIRRLMD EIKGKDRVIL ALEKELGVQA GQTQKLLLQK
   241  EALDEQLVQV KEAERHHSSP KRELPPGIGD MVELMGVQDQ HMDERDVRRF QLKIAELNSV
   301  IRKLEDRNTL LADERNELLK RSRETEVQLK PLVEKNKRMN KKNEDLLQSI QRMEEKIKNL
   361  TRENVEMKEK LSAQASLKRH TSLNDLSLTR DEQEIEFLRL QVLEQQHVID DLSLERERLL
   421  RSKRHRGKSL KPPKKHVVET FFGFDEESVD SETLSETSYN TDRTDRTPAT PEEDLDDATA
   481  REEADLRFCQ LTREYQALQR AYALLQEQVG GTLDAEREAR TREQLQADLL RCQAKIEDLE
   541  KLLVEKGQDS KWVEEKQLLI RTNQDLLEKI YRLEMEENQL KNEMQDAKDQ NELLEFRVLE
   601  LEVRDSICCK LSNGADILFE PKLKFM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JAKMIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 70 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 70 nTPM
cerebral cortex: 49 nTPM
hippocampal formation: 37 nTPM
hypothalamus: 36 nTPM
amygdala: 36 nTPM
midbrain: 24 nTPM

Single-cell type

brain inhibitory neurons: 169 nCPM
brain excitatory neurons: 103 nCPM
other brain neurons: 98 nCPM
astrocytes: 58 nCPM
t-cells: 12 nCPM
oligodendrocytes: 6.1 nCPM

Immune cell

T-reg: 37 nTPM
gdT-cell: 25 nTPM
memory CD8 T-cell: 22 nTPM
MAIT T-cell: 11 nTPM
memory CD4 T-cell: 11 nTPM
naive CD8 T-cell: 9.9 nTPM

Brain region

cerebral cortex: 55 nTPM
basal ganglia: 50 nTPM
hypothalamus: 45 nTPM
hippocampal formation: 39 nTPM
white matter: 35 nTPM
amygdala: 30 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about JAKMIP1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 104 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Smith-Magenis Syndrome-like

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 1
gnomAD missense Z: 2.89
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of JAKMIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads JAKMIP1 as an antibody target. Whether an autoantibody or antibody against JAKMIP1 could matter depends on whether native JAKMIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

JAKMIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label JAKMIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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