Seroatlas · Human Serome Atlas

InSet4-G

Protein InSETG-4

Also known as: INS4G_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: C0HMD7
Gene: InSet4-G
Canonical length: 151 aa

OverviewNCBI Gene

No narrative summary is available for InSet4-G in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

151 residues, UniProt reviewed canonical sequence.

>C0HMD7|InSet4-G
     1  MVNRHLASQG LAVKTESSVW AHSMRDCWTS VFGAGKNGEL LWISIPVACH CEQCPVLLLP
    61  AALADVLSTS SRKFSNASSA LLSPRADMVS AVIPGAPLMM LKKKELKDET KNKTACKHLC
   121  SCCPQSPLPG YCQLPGPTFP KDQPGHSEGQ R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against InSet4-G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56

OntologyGO

Cellular components

cytosol

KeywordsUniProt

Cytoplasm

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads InSet4-G as an antibody target. Whether an autoantibody or antibody against InSet4-G could matter depends on whether native InSet4-G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

InSet4-G is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label InSet4-G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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