Seroatlas · Human Serome Atlas

IVL

Involucrin

Also known as: INVO_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P07476
Gene
IVL
Ensembl
ENSG00000163207
Chromosome
1
Canonical length
585 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nuclear bodies,Centrosome,Cytosol

OverviewNCBI Gene

Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

585 residues, UniProt reviewed canonical sequence.

>P07476|IVL
     1  MSQQHTLPVT LSPALSQELL KTVPPPVNTH QEQMKQPTPL PPPCQKVPVE LPVEVPSKQE
    61  EKHMTAVKGL PEQECEQQQK EPQEQELQQQ HWEQHEEYQK AENPEQQLKQ EKTQRDQQLN
   121  KQLEEEKKLL DQQLDQELVK RDEQLGMKKE QLLELPEQQE GHLKHLEQQE GQLKHPEQQE
   181  GQLELPEQQE GQLELPEQQE GQLELPEQQE GQLELPEQQE GQLELPEQQE GQLELPQQQE
   241  GQLELSEQQE GQLELSEQQE GQLKHLEHQE GQLEVPEEQM GQLKYLEQQE GQLKHLDQQE
   301  KQPELPEQQM GQLKHLEQQE GQPKHLEQQE GQLEQLEEQE GQLKHLEQQE GQLEHLEHQE
   361  GQLGLPEQQV LQLKQLEKQQ GQPKHLEEEE GQLKHLVQQE GQLKHLVQQE GQLEQQERQV
   421  EHLEQQVGQL KHLEEQEGQL KHLEQQQGQL EVPEQQVGQP KNLEQEEKQL ELPEQQEGQV
   481  KHLEKQEAQL ELPEQQVGQP KHLEQQEKHL EHPEQQDGQL KHLEQQEGQL KDLEQQKGQL
   541  EQPVFAPAPG QVQDIQPALP TKGEVLLPVE HQQQKQEVQW PPKHK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IVL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
294 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 294 nTPM
  • vagina: 223 nTPM
  • cervix: 196 nTPM
  • skin: 156 nTPM
  • salivary gland: 85 nTPM
  • tonsil: 35 nTPM

Single-cell type

  • esophageal apical cells: 3,167 nCPM
  • esophageal suprabasal cells: 1,050 nCPM
  • suprabasal keratinocytes: 509 nCPM
  • urothelial cells: 138 nCPM
  • ocular epithelial cells: 60 nCPM
  • esophageal basal cells: 52 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
-2.37
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Involucrin repeat
  • Involucrin, N-terminal
  • Involucrin, conserved site
  • Involucrin repeat
  • Involucrin of squamous epithelia N-terminus

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IVL as an antibody target. Whether an autoantibody or antibody against IVL could matter depends on whether native IVL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IVL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IVL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IVL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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