Seroatlas · Human Serome Atlas

ITPRIPL2

Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2

Also known as: FLJ22994, IPIL2_HUMAN, LOC162073, MGC126798, MGC126800

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3MIP1
Gene: ITPRIPL2
Ensembl: ENSG00000205730
Chromosome: 16
Canonical length: 535 aa
Protein class: Predicted membrane proteins
Subcellular location: Centrosome

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

535 residues, UniProt reviewed canonical sequence.

>Q3MIP1|ITPRIPL2
     1  MSVHYTLNLR VFWPLVTGLC TALVCLYHVL RGSGGARAEP ADGVDGGFPL LKVAVLLLLS
    61  YVLLRCRHAV RQRFLPGSPR LEGHAAFSSR HFREPGLSIL LESYYEHEVR LSPHVLGHSK
   121  AHVSRIVGEL VRAGRARGSP GLIPGGALAL AFRGDFIQVG SAYEQHKIRR PDSFDVLVPL
   181  RLPPLVALEP RSLGEEPALA PAFRGCFLCA LKAPPSPSGA SGGHWLRDCK PFADAFCVDV
   241  RGRRHLSATL VLRWFQSHLQ RSLATVRYSL EGRCRVTLTP GGLEQPPTLH ILPCRTDYGC
   301  CRLSMAVRLI PAVHLGDGVF LVAPPPPPLP SAPLLELPEG LRAEALWGVN TARQEQKLLS
   361  WLQERAAPGA CYLKCLQLLK ALRDLGARGL DSAAATQWGR ILSSYVLKTV LLAVLLRKGA
   421  PGQGWDEEHL GRCLEELVQF LRDCLLRRHT LFHCVLGPGG AAAEVGPLPK ALREAAPVDL
   481  LAAFDGHARE LAAARLLSTW QRLPQLLRAY GGPRYLARCP PPRSQRTQGF LEGEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ITPRIPL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

skin: 20 nTPM
adipose tissue: 16 nTPM
placenta: 11 nTPM
lung: 11 nTPM
esophagus: 11 nTPM
urinary bladder: 11 nTPM

Single-cell type

salivary ionocytes: 1.4 nCPM
thymic myoid cells: 1.4 nCPM
breast myoepithelial cells: 0.9 nCPM
basal prostatic cells: 0.6 nCPM
microglia: 0.6 nCPM
endometrial stromal cells: 0.4 nCPM

Immune cell

intermediate monocyte: 1.5 nTPM
non-classical monocyte: 1.4 nTPM
classical monocyte: 1.2 nTPM
myeloid DC: 0.8 nTPM
basophil: 0.6 nTPM
neutrophil: 0.4 nTPM

Brain region

spinal cord: 15 nTPM
medulla oblongata: 15 nTPM
pons: 14 nTPM
midbrain: 14 nTPM
thalamus: 14 nTPM
white matter: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: 1.59
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ITPRIPL2 as an antibody target. Whether an autoantibody or antibody against ITPRIPL2 could matter depends on whether native ITPRIPL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ITPRIPL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ITPRIPL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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