Seroatlas · Human Serome Atlas

ITPRIPL1

Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

Also known as: IPIL1_HUMAN, KIAA1754L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6GPH6
Gene: ITPRIPL1
Ensembl: ENSG00000198885
Chromosome: 2
Canonical length: 555 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Enables receptor ligand activity. Involved in negative regulation of T cell receptor signaling pathway. Located in membrane. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

555 residues, UniProt reviewed canonical sequence.

>Q6GPH6|ITPRIPL1
     1  MNVDAEASMA VISLLFLAVM YVVHHPLMVS DRMDLDTLAR SRQLEKRMSE EMRLLEMEFE
    61  ERKRAAEQRQ KAENFWTGDT SSDQLVLGKK DMGWPFQADG QEGPLGWMLG NLWNTGLFCL
   121  FLVFELLRQN MQHEPAFDSS SEEEEEEVRV VPVTSYNWLT DFPSQEALDS FYKHYVQNAI
   181  RDLPCTCEFV ESFVDDLIEA CRVLSRQEAH PQLEDCLGIG AAFEKWGTLH ETQKFDILVP
   241  IVPPQGTMFV LEMRDPALGR RCGCVLVESE CVCKREKLLG DVLCLVHHHR DPSAVLGKCS
   301  SSIKAALCTG FHLDVCKTVQ WFRNMMGNAW ALVAHKYDFK LSLPPSTTSC KLRLDYRSGR
   361  FLSIHLVLGV QREDTLVYLV SQAPDQEQLT SVDWPESFVA CEHLFLKLVG RFAPENTCHL
   421  KCLQIILSLR QHQSLPHGAS RPILTSYHFK TALMHLLLRL PLTDWAHNML SQRLQDILWF
   481  LGRGLQQRSL HHFLIGNNFL PLTIPIPKTF RNAEPVNLFQ HLVLNPKAHS QAVEEFQNLL
   541  TQVKTLPHAP LAAAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ITPRIPL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

testis: 26 nTPM
salivary gland: 7.1 nTPM
thymus: 4.7 nTPM
tonsil: 4 nTPM
lymph node: 3.6 nTPM
breast: 3.5 nTPM

Single-cell type

late spermatids: 242 nCPM
early spermatids: 188 nCPM
late primary spermatocytes: 80 nCPM
lacrimal acinar cells: 24 nCPM
t-cells: 13 nCPM
megakaryocyte progenitors: 10 nCPM

Immune cell

MAIT T-cell: 13 nTPM
gdT-cell: 10 nTPM
memory CD8 T-cell: 9.7 nTPM
T-reg: 6.4 nTPM
naive CD8 T-cell: 4.1 nTPM
memory CD4 T-cell: 3.3 nTPM

Brain region

cerebellum: 7.5 nTPM
cerebral cortex: 2.9 nTPM
medulla oblongata: 2.9 nTPM
pons: 2.6 nTPM
white matter: 2.6 nTPM
thalamus: 2.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: 0.53
DepMap mean gene effect: -0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

receptor ligand activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ITPRIPL1 as an antibody target. Whether an autoantibody or antibody against ITPRIPL1 could matter depends on whether native ITPRIPL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ITPRIPL1 is annotated at the cell surface, where native ITPRIPL1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ITPRIPL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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