Seroatlas · Human Serome Atlas

ITPRID1

Protein ITPRID1

Also known as: CCDC129, FLJ38344, ITPI1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZRS4
Gene: ITPRID1
Ensembl: ENSG00000180347
Chromosome: 7
Canonical length: 1044 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable signaling receptor binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1044 residues, UniProt reviewed canonical sequence.

>Q6ZRS4|ITPRID1
     1  MMAQKSQGSD NLQEGQEKSK REILKCTKSA WAPLDEWLPP DPEEESQSLT IPMLEDSKQE
    61  SIQQWLDSGF FVSANENFQQ VIDRTVSLYE QGMVQMTVKD YMRSLHQFSE TPILSRGTSF
   121  NSCYSTASVP QSIPEWLEFW EIDPVEILLD LGFGADEPDI CMQIPARFLG CGSAARGINI
   181  RVFLEAQKQR MDIENPNLYG RFRQLEILDH VTNAFSSLLS DVSILPNRAE EKAGGESVQR
   241  TSVSAAKEHR RRMGKLLRRA SKQNIRRDCN PEVSESFKVK DEVFVPFTKP WDCGAELAAT
   301  SINHKQNHLS LSVEHQSLQA CDDLLPYPPH GLLSKQWPCS SMPAKQAPPS CVSEGSVKGR
   361  TQKENLFQTN KLKSLSHLAG KGPDSFEMEE VQSFEEETGN PLDMTSGTVG ARVDRANSCQ
   421  SDSSGFLEEP LEPLPLQMPS LPNSQSPAEN GGRKPRDQSH SLVSSQDCQL ESDGPDSKSR
   481  ASMSFSSQEA NALEQRASVS VMEEEFLLEA MEGPPELYIP DMACAKTTTR GECPRKDSHL
   541  WQLLPMPHAE YEVTRPTATS KYDHPLGFMV THVTEMQDSF VRPEGAGKVQ SHHNESQRSP
   601  GNDHTQDKFL HVDSEAPREE ESSGFCPHTN HSLLVPESSS QCIPKHSEIT PYATDLAQTS
   661  EKLIPHLHKL PGDPAQVKSR SGTLGQILPG TEAEMENLPL NTGSSRSVMT QMSSSLVSAA
   721  QRAVALGTGP RGTSLECTVC DPVTATETRL GTKARQLNDA SIQTSALSNK TLTHGPQPLT
   781  KSVSLDSGFS SICPMGTCHA IPAHCCICCH HHPHCHGERQ SPGPEPSVCR HCLCSLTGHQ
   841  EAQFMTTLKA LQDTTVRELC SCTVHEMEAM KTICQSFREY LEEIEQHLMG QQALFSRDMS
   901  EEEREEAEQL QTLREALRQQ VAELEFQLGD RAQQIREGIL LQLEVLTAEP PEHYSNLHQY
   961  NWIEESNGQT SCSKIHPGMA PRTVFPPDDG QEAPCSGGTQ LAAFTPPTLE NSTRMSPSSS
  1021  AWAKLGPTPL SNCPVGEKDA DVFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ITPRID1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 4.2 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 4.2 nTPM
midbrain: 2.4 nTPM
skin: 1.9 nTPM
cervix: 1.3 nTPM
breast: 1.2 nTPM
testis: 1.2 nTPM

Single-cell type

tuft cells: 1,914 nCPM
cardiomyocytes: 226 nCPM
breast lactating cells: 75 nCPM
astrocytes: 56 nCPM
submucosal glandular cells: 55 nCPM
early spermatids: 37 nCPM

Immune cell

naive B-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

midbrain: 34 nTPM
thalamus: 29 nTPM
cerebellum: 25 nTPM
hypothalamus: 21 nTPM
pons: 21 nTPM
white matter: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.39
gnomAD pLI: 0
DepMap mean gene effect: 0.17
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

signaling receptor binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ITPRID1 as an antibody target. Whether an autoantibody or antibody against ITPRID1 could matter depends on whether native ITPRID1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ITPRID1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ITPRID1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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