Seroatlas · Human Serome Atlas

ITPKC

Inositol-trisphosphate 3-kinase C

Also known as: IP3-3KC, IP3KC, IP3KC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96DU7
Gene
ITPKC
Ensembl
ENSG00000086544
Chromosome
19
Canonical length
683 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

This gene encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.[provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

683 residues, UniProt reviewed canonical sequence.

>Q96DU7|ITPKC
     1  MRRCPCRGSL NEAEAGALPA AARMGLEAPR GGRRRQPGQQ RPGPGAGAPA GRPEGGGPWA
    61  RTEGSSLHSE PERAGLGPAP GTESPQAEFW TDGQTEPAAA GLGVETERPK QKTEPDRSSL
   121  RTHLEWSWSE LETTCLWTET GTDGLWTDPH RSDLQFQPEE ASPWTQPGVH GPWTELETHG
   181  SQTQPERVKS WADNLWTHQN SSSLQTHPEG ACPSKEPSAD GSWKELYTDG SRTQQDIEGP
   241  WTEPYTDGSQ KKQDTEAARK QPGTGGFQIQ QDTDGSWTQP STDGSQTAPG TDCLLGEPED
   301  GPLEEPEPGE LLTHLYSHLK CSPLCPVPRL IITPETPEPE AQPVGPPSRV EGGSGGFSSA
   361  SSFDESEDDV VAGGGGASDP EDRSGSKPWK KLKTVLKYSP FVVSFRKHYP WVQLSGHAGN
   421  FQAGEDGRIL KRFCQCEQRS LEQLMKDPLR PFVPAYYGMV LQDGQTFNQM EDLLADFEGP
   481  SIMDCKMGSR TYLEEELVKA RERPRPRKDM YEKMVAVDPG APTPEEHAQG AVTKPRYMQW
   541  RETMSSTSTL GFRIEGIKKA DGTCNTNFKK TQALEQVTKV LEDFVDGDHV ILQKYVACLE
   601  ELREALEISP FFKTHEVVGS SLLFVHDHTG LAKVWMIDFG KTVALPDHQT LSHRLPWAEG
   661  NREDGYLWGL DNMICLLQGL AQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ITPKC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
94 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 94 nTPM
  • skin: 49 nTPM
  • adipose tissue: 43 nTPM
  • vagina: 41 nTPM
  • lung: 40 nTPM
  • choroid plexus: 35 nTPM

Single-cell type

  • esophageal apical cells: 1,076 nCPM
  • ocular epithelial cells: 995 nCPM
  • urothelial cells: 917 nCPM
  • esophageal suprabasal cells: 758 nCPM
  • respiratory basal cells: 737 nCPM
  • suprabasal keratinocytes: 677 nCPM

Immune cell

  • basophil: 1 nTPM
  • gdT-cell: 0.7 nTPM
  • classical monocyte: 0.6 nTPM
  • memory CD4 T-cell: 0.6 nTPM
  • naive B-cell: 0.6 nTPM
  • non-classical monocyte: 0.5 nTPM

Brain region

  • thalamus: 22 nTPM
  • medulla oblongata: 20 nTPM
  • pons: 14 nTPM
  • choroid plexus: 13 nTPM
  • midbrain: 13 nTPM
  • amygdala: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.15
gnomAD missense Z
0.53
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ITPKC as an antibody target. Whether an autoantibody or antibody against ITPKC could matter depends on whether native ITPKC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ITPKC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ITPKC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ITPKC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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