Seroatlas · Human Serome Atlas

ITPKB

Inositol-trisphosphate 3-kinase B

Also known as: IP3-3KB, IP3KB, IP3KB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P27987
Gene: ITPKB
Ensembl: ENSG00000143772
Chromosome: 1
Canonical length: 946 aa
Protein class: Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

946 residues, UniProt reviewed canonical sequence.

>P27987|ITPKB
     1  MAVYCYALNS LVIMNSANEM KSGGGPGPSG SETPPPPRRA VLSPGSVFSP GRGASFLFPP
    61  AESLSPEEPR SPGGWRSGRR RLNSSSGSGS GSSGSSVSSP SWAGRLRGDR QQVVAAGTLS
   121  PPGPEEAKRK LRILQRELQN VQVNQKVGMF EAHIQAQSSA IQAPRSPRLG RARSPSPCPF
   181  RSSSQPPGRV LVQGARSEER RTKSWGEQCP ETSGTDSGRK GGPSLCSSQV KKGMPPLPGR
   241  AAPTGSEAQG PSAFVRMEKG IPASPRCGSP TAMEIDKRGS PTPGTRSCLA PSLGLFGASL
   301  TMATEVAARV TSTGPHRPQD LALTEPSGRA RELEDLQPPE ALVERQGQFL GSETSPAPER
   361  GGPRDGEPPG KMGKGYLPCG MPGSGEPEVG KRPEETTVSV QSAESSDSLS WSRLPRALAS
   421  VGPEEARSGA PVGGGRWQLS DRVEGGSPTL GLLGGSPSAQ PGTGNVEAGI PSGRMLEPLP
   481  CWDAAKDLKE PQCPPGDRVG VQPGNSRVWQ GTMEKAGLAW TRGTGVQSEG TWESQRQDSD
   541  ALPSPELLPQ DPDKPFLRKA CSPSNIPAVI ITDMGTQEDG ALEETQGSPR GNLPLRKLSS
   601  SSASSTGFSS SYEDSEEDIS SDPERTLDPN SAFLHTLDQQ KPRVSKSWRK IKNMVHWSPF
   661  VMSFKKKYPW IQLAGHAGSF KAAANGRILK KHCESEQRCL DRLMVDVLRP FVPAYHGDVV
   721  KDGERYNQMD DLLADFDSPC VMDCKMGIRT YLEEELTKAR KKPSLRKDMY QKMIEVDPEA
   781  PTEEEKAQRA VTKPRYMQWR ETISSTATLG FRIEGIKKED GTVNRDFKKT KTREQVTEAF
   841  REFTKGNHNI LIAYRDRLKA IRTTLEVSPF FKCHEVIGSS LLFIHDKKEQ AKVWMIDFGK
   901  TTPLPEGQTL QHDVPWQEGN REDGYLSGLN NLVDILTEMS QDAPLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ITPKB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 99 nTPM

Expression across tissuesHPA

Tissue

midbrain: 99 nTPM
choroid plexus: 90 nTPM
basal ganglia: 68 nTPM
amygdala: 64 nTPM
spinal cord: 61 nTPM
cerebral cortex: 51 nTPM

Single-cell type

choroid plexus epithelial cells: 889 nCPM
distal convoluted tubule cells: 420 nCPM
astrocytes: 373 nCPM
ependymal cells: 307 nCPM
bergmann glia: 212 nCPM
t-cells: 190 nCPM

Immune cell

eosinophil: 5 nTPM
naive CD4 T-cell: 4.5 nTPM
naive CD8 T-cell: 3.4 nTPM
neutrophil: 3.2 nTPM
memory CD4 T-cell: 3.1 nTPM
memory CD8 T-cell: 2.6 nTPM

Brain region

medulla oblongata: 379 nTPM
thalamus: 373 nTPM
basal ganglia: 356 nTPM
midbrain: 324 nTPM
spinal cord: 261 nTPM
cerebellum: 252 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.15
gnomAD pLI: 1
gnomAD missense Z: 0.64
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ITPKB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DMTN

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ITPKB as an antibody target. Whether an autoantibody or antibody against ITPKB could matter depends on whether native ITPKB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ITPKB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ITPKB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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