Seroatlas · Human Serome Atlas

ITM2A

Integral membrane protein 2A

Also known as: BRICD2A, E25A, ITM2A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43736
Gene: ITM2A
Ensembl: ENSG00000078596
Chromosome: X
Canonical length: 263 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus,Vesicles,Plasma membrane

OverviewNCBI Gene

This gene encodes a type II membrane protein that belongs to the ITM2 family. Studies in mouse suggest that it may be involved in osteo- and chondrogenic differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Canonical amino-acid sequenceUniProt

263 residues, UniProt reviewed canonical sequence.

>O43736|ITM2A
     1  MVKIAFNTPT AVQKEEARQD VEALLSRTVR TQILTGKELR VATQEKEGSS GRCMLTLLGL
    61  SFILAGLIVG GACIYKYFMP KSTIYRGEMC FFDSEDPANS LRGGEPNFLP VTEEADIRED
   121  DNIAIIDVPV PSFSDSDPAA IIHDFEKGMT AYLDLLLGNC YLMPLNTSIV MPPKNLVELF
   181  GKLASGRYLP QTYVVREDLV AVEEIRDVSN LGIFIYQLCN NRKSFRLRRR DLLLGFNKRA
   241  IDKCWKIRHF PNEFIVETKI CQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ITM2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 301 nTPM

Expression across tissuesHPA

Tissue

thymus: 301 nTPM
ovary: 148 nTPM
heart muscle: 108 nTPM
basal ganglia: 94 nTPM
lymph node: 82 nTPM
hippocampal formation: 80 nTPM

Single-cell type

vascular endothelial cells: 294 nCPM
ovarian stromal cells: 201 nCPM
breast myoepithelial cells: 196 nCPM
t-cells: 195 nCPM
fibroblasts: 192 nCPM
lacrimal acinar cells: 191 nCPM

Immune cell

naive CD4 T-cell: 217 nTPM
memory CD4 T-cell: 205 nTPM
basophil: 173 nTPM
memory CD8 T-cell: 170 nTPM
T-reg: 168 nTPM
NK-cell: 131 nTPM

Brain region

thalamus: 98 nTPM
hypothalamus: 86 nTPM
amygdala: 83 nTPM
cerebral cortex: 81 nTPM
pons: 80 nTPM
midbrain: 78 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0.2
gnomAD missense Z: 0.13
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

amyloid-beta binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ITM2A as an antibody target. Whether an autoantibody or antibody against ITM2A could matter depends on whether native ITM2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ITM2A is annotated at the cell surface, where native ITM2A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ITM2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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