ITLN2
Intelectin-2
Also known as: HL-2, ITLN2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8WWU7
- Gene
- ITLN2
- Ensembl
- ENSG00000158764
- Chromosome
- 1
- Canonical length
- 325 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted to digestive system
OverviewNCBI Gene
Predicted to enable oligosaccharide binding activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
325 residues, UniProt reviewed canonical sequence.
>Q8WWU7|ITLN2
1 MLSMLRTMTR LCFLLFFSVA TSGCSAAAAS SLEMLSREFE TCAFSFSSLP RSCKEIKERC
61 HSAGDGLYFL RTKNGVVYQT FCDMTSGGGG WTLVASVHEN DMRGKCTVGD RWSSQQGNKA
121 DYPEGDGNWA NYNTFGSAEA ATSDDYKNPG YYDIQAKDLG IWHVPNKSPM QHWRNSALLR
181 YRTNTGFLQR LGHNLFGIYQ KYPVKYRSGK CWNDNGPAIP VVYDFGDAKK TASYYSPYGQ
241 REFVAGFVQF RVFNNERAAN ALCAGIKVTG CNTEHHCIGG GGFFPQGKPR QCGDFSAFDW
301 DGYGTHVKSS CSREITEAAV LLFYRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ITLN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.25
- Highest tissue expression
- 384 nTPM
Expression across tissuesHPA
Tissue
- small intestine: 384 nTPM
- duodenum: 224 nTPM
- lung: 11 nTPM
- adipose tissue: 6.5 nTPM
- blood vessel: 2.1 nTPM
- ovary: 1.4 nTPM
Single-cell type
- paneth cells: 1,903 nCPM
- mesothelial cells: 39 nCPM
- alveolar cells type 1: 16 nCPM
- ovarian stromal cells: 4.1 nCPM
- peritubular myoid cells: 3.8 nCPM
- goblet cells: 2.4 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- medulla oblongata: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.12
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.33
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ITLN2 as an antibody target. Whether an autoantibody or antibody against ITLN2 could matter depends on whether native ITLN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ITLN2 is annotated as secreted, so native ITLN2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label ITLN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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