Seroatlas · Human Serome Atlas

ITLN1

Intelectin-1

Also known as: FLJ20022, hIntL, HL-1, ITLN, ITLN1_HUMAN, LFR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WWA0
Gene: ITLN1
Ensembl: ENSG00000179914
Chromosome: 1
Canonical length: 313 aa
Protein class: Plasma proteins, Predicted secreted proteins
Subcellular location: Vesicles,Acrosome,Equatorial segment,Mid piece,Principal piece
Secretome location: Secreted to blood
Quaternary structure: Homotrimer

OverviewNCBI Gene

Enables calcium ion binding activity; identical protein binding activity; and oligosaccharide binding activity. Involved in positive regulation of D-glucose import; positive regulation of protein phosphorylation; and protein homotrimerization. Located in extracellular exosome. Part of receptor complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>Q8WWA0|ITLN1
     1  MNQLSFLLFL IATTRGWSTD EANTYFKEWT CSSSPSLPRS CKEIKDECPS AFDGLYFLRT
    61  ENGVIYQTFC DMTSGGGGWT LVASVHENDM RGKCTVGDRW SSQQGSKAVY PEGDGNWANY
   121  NTFGSAEAAT SDDYKNPGYY DIQAKDLGIW HVPNKSPMQH WRNSSLLRYR TDTGFLQTLG
   181  HNLFGIYQKY PVKYGEGKCW TDNGPVIPVV YDFGDAQKTA SYYSPYGQRE FTAGFVQFRV
   241  FNNERAANAL CAGMRVTGCN TEHHCIGGGG YFPEASPQQC GDFSGFDWSG YGTHVGYSSS
   301  REITEAAVLL FYR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ITLN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 1,173 nTPM

Expression across tissuesHPA

Tissue

rectum: 1,173 nTPM
adipose tissue: 715 nTPM
colon: 417 nTPM
small intestine: 391 nTPM
duodenum: 257 nTPM
heart muscle: 220 nTPM

Single-cell type

mesothelial cells: 8,632 nCPM
goblet cells: 1,958 nCPM
kupffer cells: 358 nCPM
thymic myoid cells: 109 nCPM
medullary thymic epithelial cells: 58 nCPM
fibro-adipogenic progenitors: 47 nCPM

Immune cell

non-classical monocyte: 24 nTPM
intermediate monocyte: 9.2 nTPM
myeloid DC: 1.4 nTPM
classical monocyte: 0.5 nTPM
total PBMC: 0.4 nTPM
neutrophil: 0.2 nTPM

Brain region

cerebral cortex: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: 0.43
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ITLN1 as an antibody target. Whether an autoantibody or antibody against ITLN1 could matter depends on whether native ITLN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ITLN1 is annotated at the cell surface, where native ITLN1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ITLN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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