Seroatlas · Human Serome Atlas

ITGBL1

Integrin beta-like protein 1

Also known as: ITGBL_HUMAN, OSCP, TIED

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95965
Gene: ITGBL1
Ensembl: ENSG00000198542
Chromosome: 13
Canonical length: 494 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins, Transporters
Secretome location: Secreted - unknown location

OverviewNCBI Gene

This gene encodes a beta integrin-related protein that is a member of the EGF-like protein family. The encoded protein contains integrin-like cysteine-rich repeats. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

494 residues, UniProt reviewed canonical sequence.

>O95965|ITGBL1
     1  MRPPGFRNFL LLASSLLFAG LSAVPQSFSP SLRSWPGAAC RLSRAESERR CRAPGQPPGA
    61  ALCHGRGRCD CGVCICHVTE PGMFFGPLCE CHEWVCETYD GSTCAGHGKC DCGKCKCDQG
   121  WYGDACQYPT NCDLTKKKSN QMCKNSQDII CSNAGTCHCG RCKCDNSDGS GLVYGKFCEC
   181  DDRECIDDET EEICGGHGKC YCGNCYCKAG WHGDKCEFQC DITPWESKRR CTSPDGKICS
   241  NRGTCVCGEC TCHDVDPTGD WGDIHGDTCE CDERDCRAVY DRYSDDFCSG HGQCNCGRCD
   301  CKAGWYGKKC EHPQSCTLSA EESIRKCQGS SDLPCSGRGK CECGKCTCYP PGDRRVYGKT
   361  CECDDRRCED LDGVVCGGHG TCSCGRCVCE RGWFGKLCQH PRKCNMTEEQ SKNLCESADG
   421  ILCSGKGSCH CGKCICSAEE WYISGEFCDC DDRDCDKHDG LICTGNGICS CGNCECWDGW
   481  NGNACEIWLG SEYP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ITGBL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 157 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 157 nTPM
gallbladder: 36 nTPM
placenta: 31 nTPM
lung: 24 nTPM
cervix: 22 nTPM
heart muscle: 17 nTPM

Single-cell type

thymic myoid cells: 336 nCPM
pituicytes/fscs: 281 nCPM
gonadotrophs: 280 nCPM
pituitary stem cells: 242 nCPM
myosatellite cells: 230 nCPM
retinal pigment epithelial cells: 196 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 14 nTPM
cerebellum: 9.4 nTPM
hypothalamus: 7.9 nTPM
medulla oblongata: 7.8 nTPM
spinal cord: 7.7 nTPM
pons: 5.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 0.58
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

integrin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ITGBL1 as an antibody target. Whether an autoantibody or antibody against ITGBL1 could matter depends on whether native ITGBL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ITGBL1 is annotated as secreted, so native ITGBL1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ITGBL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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