Seroatlas · Human Serome Atlas

ISOC2

Isochorismatase domain-containing protein 2

Also known as: FLJ23469, ISOC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96AB3
Gene: ISOC2
Ensembl: ENSG00000063241
Chromosome: 19
Canonical length: 205 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria,Cytosol

OverviewNCBI Gene

Involved in protein destabilization. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>Q96AB3|ISOC2
     1  MAAARPSLGR VLPGSSVLFL CDMQEKFRHN IAYFPQIVSV AARMLKVARL LEVPVMLTEQ
    61  YPQGLGPTVP ELGTEGLRPL AKTCFSMVPA LQQELDSRPQ LRSVLLCGIE AQACILNTTL
   121  DLLDRGLQVH VVVDACSSRS QVDRLVALAR MRQSGAFLST SEGLILQLVG DAVHPQFKEI
   181  QKLIKEPAPD SGLLGLFQGQ NSLLH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ISOC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 263 nTPM

Expression across tissuesHPA

Tissue

liver: 263 nTPM
kidney: 95 nTPM
skeletal muscle: 90 nTPM
choroid plexus: 78 nTPM
heart muscle: 65 nTPM
testis: 62 nTPM

Single-cell type

hepatocytes: 322 nCPM
late primary spermatocytes: 317 nCPM
enterocytes: 231 nCPM
esophageal basal cells: 200 nCPM
enteric transient amplifying cells: 162 nCPM
colonocytes: 159 nCPM

Immune cell

intermediate monocyte: 34 nTPM
myeloid DC: 30 nTPM
non-classical monocyte: 28 nTPM
NK-cell: 24 nTPM
plasmacytoid DC: 24 nTPM
memory B-cell: 19 nTPM

Brain region

choroid plexus: 46 nTPM
medulla oblongata: 43 nTPM
midbrain: 38 nTPM
white matter: 37 nTPM
hypothalamus: 37 nTPM
pons: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.55
gnomAD pLI: 0
gnomAD missense Z: -0.04
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein destabilization

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ISOC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CDKN2A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ISOC2 as an antibody target. Whether an autoantibody or antibody against ISOC2 could matter depends on whether native ISOC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ISOC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ISOC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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