Seroatlas · Human Serome Atlas

ISOC1

Isochorismatase domain-containing protein 1

Also known as: CGI-111, ISOC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96CN7
Gene: ISOC1
Ensembl: ENSG00000066583
Chromosome: 5
Canonical length: 298 aa
Protein class: Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum,Vesicles

OverviewNCBI Gene

Predicted to be located in peroxisome. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

298 residues, UniProt reviewed canonical sequence.

>Q96CN7|ISOC1
     1  MAAAEPAVLA LPNSGAGGAG APSGTVPVLF CFSVFARPSS VPHGAGYELL IQKFLSLYGD
    61  QIDMHRKFVV QLFAEEWGQY VDLPKGFAVS ERCKVRLVPL QIQLTTLGNL TPSSTVFFCC
   121  DMQERFRPAI KYFGDIISVG QRLLQGARIL GIPVIVTEQY PKGLGSTVQE IDLTGVKLVL
   181  PKTKFSMVLP EVEAALAEIP GVRSVVLFGV ETHVCIQQTA LELVGRGVEV HIVADATSSR
   241  SMMDRMFALE RLARTGIIVT TSEAVLLQLV ADKDHPKFKE IQNLIKASAP ESGLLSKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ISOC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 96 nTPM

Expression across tissuesHPA

Tissue

endometrium: 96 nTPM
liver: 94 nTPM
heart muscle: 62 nTPM
smooth muscle: 61 nTPM
cervix: 54 nTPM
kidney: 31 nTPM

Single-cell type

oocytes: 124 nCPM
parietal cells: 124 nCPM
basal keratinocytes: 119 nCPM
hepatocytes: 109 nCPM
cytotrophoblasts: 88 nCPM
extravillous trophoblasts: 88 nCPM

Immune cell

T-reg: 69 nTPM
basophil: 64 nTPM
MAIT T-cell: 62 nTPM
NK-cell: 61 nTPM
memory CD8 T-cell: 58 nTPM
gdT-cell: 54 nTPM

Brain region

midbrain: 24 nTPM
medulla oblongata: 22 nTPM
hypothalamus: 22 nTPM
white matter: 21 nTPM
pons: 18 nTPM
spinal cord: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0
gnomAD missense Z: 0.31
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ISOC1 as an antibody target. Whether an autoantibody or antibody against ISOC1 could matter depends on whether native ISOC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ISOC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ISOC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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