ISLR2

Protein identityUniProt · HPA

UniProt accession

Q6UXK2

Gene

ISLR2

Ensembl

ENSG00000167178

Chromosome

15

Canonical length

745 aa

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Quaternary structure

Homomultimer

OverviewNCBI Gene

Predicted to be involved in positive regulation of axon extension. Predicted to be located in plasma membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

745 residues, UniProt reviewed canonical sequence.

>Q6UXK2|ISLR2
     1  MFPLRALWLV WALLGVAGSC PEPCACVDKY AHQFADCAYK ELREVPEGLP ANVTTLSLSA
    61  NKITVLRRGA FADVTQVTSL WLAHNEVRTV EPGALAVLSQ LKNLDLSHNF ISSFPWSDLR
   121  NLSALQLLKM NHNRLGSLPR DALGALPDLR SLRINNNRLR TLAPGTFDAL SALSHLQLYH
   181  NPFHCGCGLV WLQAWAASTR VSLPEPDSIA CASPPALQGV PVYRLPALPC APPSVHLSAE
   241  PPLEAPGTPL RAGLAFVLHC IADGHPTPRL QWQLQIPGGT VVLEPPVLSG EDDGVGAEEG
   301  EGEGDGDLLT QTQAQTPTPA PAWPAPPATP RFLALANGSL LVPLLSAKEA GVYTCRAHNE
   361  LGANSTSIRV AVAATGPPKH APGAGGEPDG QAPTSERKST AKGRGNSVLP SKPEGKIKGQ
   421  GLAKVSILGE TETEPEEDTS EGEEAEDQIL ADPAEEQRCG NGDPSRYVSN HAFNQSAELK
   481  PHVFELGVIA LDVAEREARV QLTPLAARWG PGPGGAGGAP RPGRRPLRLL YLCPAGGGAA
   541  VQWSRVEEGV NAYWFRGLRP GTNYSVCLAL AGEACHVQVV FSTKKELPSL LVIVAVSVFL
   601  LVLATVPLLG AACCHLLAKH PGKPYRLILR PQAPDPMEKR IAADFDPRAS YLESEKSYPA
   661  GGEAGGEEPE DVQGEGLDED AEQGDPSGDL QREESLAACS LVESQSKANQ EEFEAGSEYS
   721  DRLPLGAEAV NIAQEINGNY RQTAG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ISLR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.47

Highest tissue expression

16 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ISLR2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 88 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Developmental and epileptic encephalopathy, 33

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.58

gnomAD pLI

0.11

gnomAD missense Z

2.24

DepMap mean gene effect

-0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• nervous system development
• positive regulation of axon extension

Cellular components

• cell surface
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Cysteine-rich flanking region, C-terminal
• Leucine-rich repeat
• Leucine-rich repeat, typical subtype
• Immunoglobulin-like domain
• Immunoglobulin-like fold
• Leucine-rich repeat domain superfamily
• Immunoglobulin-like domain superfamily
• Leucine rich repeat

KeywordsUniProt

• Cell membrane
• Developmental protein
• Disulfide bond
• Glycoprotein
• Immunoglobulin domain
• Leucine-rich repeat
• Membrane
• Neurogenesis
• Phosphoprotein
• Repeat
• Signal
• Transmembrane
• Transmembrane helix