Seroatlas · Human Serome Atlas

ISLR

Immunoglobulin superfamily containing leucine-rich repeat protein

Also known as: HsT17563, ISLR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14498
Gene: ISLR
Ensembl: ENSG00000129009
Chromosome: 15
Canonical length: 428 aa
Protein class: Predicted secreted proteins
Subcellular location: Golgi apparatus,Plasma membrane
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Predicted to be involved in cell adhesion. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

428 residues, UniProt reviewed canonical sequence.

>O14498|ISLR
     1  MQELHLLWWA LLLGLAQACP EPCDCGEKYG FQIADCAYRD LESVPPGFPA NVTTLSLSAN
    61  RLPGLPEGAF REVPLLQSLW LAHNEIRTVA AGALASLSHL KSLDLSHNLI SDFAWSDLHN
   121  LSALQLLKMD SNELTFIPRD AFRSLRALRS LQLNHNRLHT LAEGTFTPLT ALSHLQINEN
   181  PFDCTCGIVW LKTWALTTAV SIPEQDNIAC TSPHVLKGTP LSRLPPLPCS APSVQLSYQP
   241  SQDGAELRPG FVLALHCDVD GQPAPQLHWH IQIPSGIVEI TSPNVGTDGR ALPGTPVASS
   301  QPRFQAFANG SLLIPDFGKL EEGTYSCLAT NELGSAESSV DVALATPGEG GEDTLGRRFH
   361  GKAVEGKGCY TVDNEVQPSG PEDNVVIIYL SRAGNPEAAV AEGVPGQLPP GLLLLGQSLL
   421  LFFFLTSF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ISLR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 214 nTPM

Expression across tissuesHPA

Tissue

cervix: 214 nTPM
endometrium: 180 nTPM
ovary: 163 nTPM
blood vessel: 119 nTPM
vagina: 107 nTPM
fallopian tube: 91 nTPM

Single-cell type

fibroblasts: 14 nCPM
ependymal cells: 1.5 nCPM
astrocytes: 1.3 nCPM
vascular smooth muscle cells: 1 nCPM
papillary tip epithelial cells: 0.9 nCPM
pericytes: 0.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 24 nTPM
choroid plexus: 11 nTPM
hypothalamus: 10 nTPM
white matter: 9.2 nTPM
thalamus: 8.8 nTPM
amygdala: 8.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ISLR.

Disease | ImmuneIEDB

Conditions an epitope on ISLR was assayed in.

Lyme disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0.02
gnomAD missense Z: 0.93
DepMap mean gene effect: 0.17
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell adhesion

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ISLR as an antibody target. Whether an autoantibody or antibody against ISLR could matter depends on whether native ISLR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ISLR is annotated as secreted, so native ISLR circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ISLR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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