Seroatlas · Human Serome Atlas

IRX2-DT

Putative uncharacterized protein IRX2-DT

Also known as: CEI_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86SI9
Gene: IRX2-DT
Canonical length: 138 aa

OverviewNCBI Gene

No narrative summary is available for IRX2-DT in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

138 residues, UniProt reviewed canonical sequence.

>Q86SI9|IRX2-DT
     1  MVAPAARVFL RAVRAALTST VPDLLCLLAR GSPRGLASGR LPLAVHSAQH GPGSGAPWLR
    61  IARRALRFVL SKHWGDDCYL TNRLWQDLKP PSHVENGQEL RLAPPVQWAL QVQGNQLQTA
   121  VLCLRMAPPE PAGSRQRI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IRX2-DT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular region

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IRX2-DT as an antibody target. Whether an autoantibody or antibody against IRX2-DT could matter depends on whether native IRX2-DT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IRX2-DT is annotated as secreted, so native IRX2-DT circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label IRX2-DT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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