Seroatlas · Human Serome Atlas

IRAG1

Inositol 1,4,5-triphosphate receptor associated 1

Also known as: IRAG, IRAG1_HUMAN, JAW1L, MRVI1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y6F6
Gene
IRAG1
Ensembl
ENSG00000072952
Chromosome
11
Canonical length
904 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nuclear bodies,Cytosol

OverviewNCBI Gene

This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

904 residues, UniProt reviewed canonical sequence.

>Q9Y6F6|IRAG1
     1  MGMDLTCPFG ISPACGAQAS WSIFGADAAE VPGTRGHSQQ EAAMPHIPED EEPPGEPQAA
    61  QSPAGQGPPA AGVSCSPTPT IVLTGDATSP EGETDKNLAN RVHSPHKRLS HRHLKVSTAS
   121  LTSVDPAGHI IDLVNDQLPD ISISEEDKKK NLALLEEAKL VSERFLTRRG RKSRSSPGDS
   181  PSAVSPNLSP SASPTSSRSN SLTVPTPPGL DVCSGPPSPL PGAPPQQKGD EADVSSPHPG
   241  EPNVPKGLAD RKQNDQRKVS QGRLAPRPPP VEKSKEIAIE QKENFDPLQY PETTPKGLAP
   301  VTNSSGKMAL NSPQPGPVES ELGKQLLKTG WEGSPLPRSP TQDAAGVGPP ASQGRGPAGE
   361  PMGPEAGSKA ELPPTVSRPP LLRGLSWDSG PEEPGPRLQK VLAKLPLAEE EKRFAGKAGG
   421  KLAKAPGLKD FQIQVQPVRM QKLTKLREEH ILMRNQNLVG LKLPDLSEAA EQEKGLPSEL
   481  SPAIEEEESK SGLDVMPNIS DVLLRKLRVH RSLPGSAPPL TEKEVENVFV QLSLAFRNDS
   541  YTLESRINQA ERERNLTEEN TEKELENFKA SITSSASLWH HCEHRETYQK LLEDIAVLHR
   601  LAARLSSRAE VVGAVRQEKR MSKATEVMMQ YVENLKRTYE KDHAELMEFK KLANQNSSRS
   661  CGPSEDGVPR TARSMSLTLG KNMPRRRVSV AVVPKFNALN LPGQTPSSSS IPSLPALSES
   721  PNGKGSLPVT SALPALLENG KTNGDPDCEA SAPALTLSCL EELSQETKAR MEEEAYSKGF
   781  QEGLKKTKEL QDLKEEEEEQ KSESPEEPEE VEETEEEEKG PRSSKLEELV HFLQVMYPKL
   841  CQHWQVIWMM AAVMLVLTVV LGLYNSYNSC AEQADGPLGR STCSAAQRDS WWSSGLQHEQ
   901  PTEQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IRAG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
162 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 162 nTPM
  • smooth muscle: 65 nTPM
  • colon: 64 nTPM
  • cervix: 57 nTPM
  • endometrium: 54 nTPM
  • fallopian tube: 50 nTPM

Single-cell type

  • astrocytes: 183 nCPM
  • vascular smooth muscle cells: 161 nCPM
  • pericytes: 105 nCPM
  • smooth muscle cells: 64 nCPM
  • peritubular myoid cells: 46 nCPM
  • bergmann glia: 38 nCPM

Immune cell

  • neutrophil: 24 nTPM
  • non-classical monocyte: 5.7 nTPM
  • intermediate monocyte: 3.9 nTPM
  • classical monocyte: 2.2 nTPM
  • eosinophil: 1.7 nTPM
  • naive B-cell: 0.9 nTPM

Brain region

  • thalamus: 166 nTPM
  • basal ganglia: 152 nTPM
  • midbrain: 126 nTPM
  • medulla oblongata: 114 nTPM
  • amygdala: 109 nTPM
  • spinal cord: 91 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.63
gnomAD pLI
0
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IRAG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IRAG1 as an antibody target. Whether an autoantibody or antibody against IRAG1 could matter depends on whether native IRAG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IRAG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IRAG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IRAG1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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