IQCK
IQ domain-containing protein K
Also known as: FLJ36575, IQCK_HUMAN, MGC35048
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N0W5
- Gene
- IQCK
- Ensembl
- ENSG00000174628
- Chromosome
- 16
- Canonical length
- 287 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nuclear speckles,Cytosol
OverviewNCBI Gene
This gene belongs to the IQ motif-containing family of proteins. The IQ motif serves as a binding site for different EF-hand proteins such as calmodulin. This gene was identified as a potential candidate gene for obsessive-compulsive disorder in a genome-wide association study. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Canonical amino-acid sequenceUniProt
287 residues, UniProt reviewed canonical sequence.
>Q8N0W5|IQCK
1 MAAPRQIPSH IVRLKPSCST DSSFTRTPVP TVSLASRELP VSSWQVTEPS SKNLWEQICK
61 EYEAEQPPFP EGYKVKQEPV ITVAPVEEML FHGFSAEHYF PVSHFTMISR TPCPQDKSET
121 INPKTCSPKE YLETFIFPVL LPGMASLLHQ AKKEKCFERK RTKFIACDFL TEWLYNQNPK
181 RAGEPFTEFF SIPFVEERLK QHPRPPIPLS LLLTEEEAAL YIQSFWRACV VRCDPEIQEL
241 RQWQKKLREA KHIHQQVKIF WAKQEQKVKC KMEDDAVPAA KMKIPSSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IQCK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.56
- Highest tissue expression
- 21 nTPM
Expression across tissuesHPA
Tissue
- testis: 21 nTPM
- fallopian tube: 20 nTPM
- parathyroid gland: 18 nTPM
- thyroid gland: 18 nTPM
- choroid plexus: 15 nTPM
- epididymis: 15 nTPM
Single-cell type
- ependymal cells: 354 nCPM
- rod photoreceptor cells: 340 nCPM
- respiratory ciliated cells: 333 nCPM
- fallopian tube ciliated cells: 231 nCPM
- bergmann glia: 230 nCPM
- cone photoreceptor cells: 228 nCPM
Immune cell
- intermediate monocyte: 1.3 nTPM
- non-classical monocyte: 1.3 nTPM
- naive CD4 T-cell: 1 nTPM
- MAIT T-cell: 0.9 nTPM
- memory CD8 T-cell: 0.8 nTPM
- gdT-cell: 0.5 nTPM
Brain region
- hypothalamus: 17 nTPM
- choroid plexus: 16 nTPM
- white matter: 15 nTPM
- midbrain: 13 nTPM
- spinal cord: 12 nTPM
- medulla oblongata: 11 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.15
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.01
- DepMap mean gene effect
- 0
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- IQ domain-containing protein K
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IQCK as an antibody target. Whether an autoantibody or antibody against IQCK could matter depends on whether native IQCK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IQCK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label IQCK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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