Seroatlas · Human Serome Atlas

IQCJ-SCHIP1

IQCJ-SCHIP1 readthrough transcript protein

Also known as: IQIP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
B3KU38
Gene
IQCJ-SCHIP1
Ensembl
ENSG00000283154
Chromosome
3
Canonical length
563 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol
Quaternary structure
Homooligomer

OverviewNCBI Gene

This locus represents naturally occurring read-through transcription from the neighboring IQ motif containing J (IQCJ) and schwannomin interacting protein 1 (SCHIP1) genes. Alternative splicing results in multiple transcript variants that are composed of in-frame exons from each individual gene. The resulting fusion products are thought to be components of the multimolecular complexes of axon initial segments and nodes of Ranvier, and they may play a role in calcium-mediated responses. [provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

563 residues, UniProt reviewed canonical sequence.

>B3KU38|IQCJ-SCHIP1
     1  MRLEELKRLQ NPLEQVNDGK YSFENHQLAM DAENNIEKYP LNLQPLESKV KIIQRAWREY
    61  LQRQEPLGKR SPSPPSVSSE KLSSSVSMNT FSDSSTPDYR EDGMDLGSDA GSSSSSSRAS
   121  SQSNSTKVTP CSECKSSSSP GGSLDLVSAL EDYEEPFPVY QKKVIDEWAP EEDGEEEEEE
   181  DERDQRGYRD DRSPAREPGD VSARTRSGGG GGRSATTAMP PPVPNGNLHQ HDPQDLRHNG
   241  NVVVAGRPSC SRGPRRAIQK PQPAGGRRSG RGPAAGGLCL QPPDGGTCVP EEPPVPPMDW
   301  EALEKHLAGL QFREQEVRNQ GQARTNSTSA QKNERESIRQ KLALGSFFDD GPGIYTSCSK
   361  SGKPSLSSRL QSGMNLQICF VNDSGSDKDS DADDSKTETS LDTPLSPMSK QSSSYSDRDT
   421  TEEESESLDD MDFLTRQKKL QAEAKMALAM AKPMAKMQVE VEKQNRKKSP VADLLPHMPH
   481  ISECLMKRSL KPTDLRDMTI GQLQVIVNDL HSQIESLNEE LVQLLLIRDE LHTEQDAMLV
   541  DIEDLTRHAE SQQKHMAEKM PAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IQCJ-SCHIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
91 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 91 nTPM
  • hippocampal formation: 62 nTPM
  • cerebral cortex: 54 nTPM
  • midbrain: 51 nTPM
  • amygdala: 48 nTPM
  • heart muscle: 43 nTPM

Single-cell type

  • pituitary stem cells: 9,936 nCPM
  • podocytes: 2,999 nCPM
  • retinal bipolar cells: 1,870 nCPM
  • cone photoreceptor cells: 623 nCPM
  • retinal horizontal cells: 521 nCPM
  • retinal ganglion cells: 460 nCPM

Immune cell

  • plasmacytoid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • white matter: 124 nTPM
  • medulla oblongata: 94 nTPM
  • pons: 90 nTPM
  • basal ganglia: 85 nTPM
  • midbrain: 81 nTPM
  • thalamus: 80 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.53
gnomAD pLI
0.03
gnomAD missense Z
0.69

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IQCJ-SCHIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IQCJ-SCHIP1 as an antibody target. Whether an autoantibody or antibody against IQCJ-SCHIP1 could matter depends on whether native IQCJ-SCHIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IQCJ-SCHIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IQCJ-SCHIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IQCJ-SCHIP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...