Seroatlas · Human Serome Atlas

IQCJ

IQ domain-containing protein J

Also known as: IQCJ_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q1A5X6
Gene
IQCJ
Ensembl
ENSG00000214216
Chromosome
3
Canonical length
159 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for IQCJ in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

159 residues, UniProt reviewed canonical sequence.

>Q1A5X6|IQCJ
     1  MRLEELKRLQ NPLEQVNDGK YSFENHQLAM DAENNIEKYP LNLQPLESKV KIIQRAWREY
    61  LQRQEPLGKR SPSPPSVSSE KLSSSVSMNT FSDSSTPFAR APVGKIHPYI SWRLQSPGDK
   121  LPGGRKVILL YLDQLARPTG FIHTLKEPQI ERLGFLTLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IQCJ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
0.8 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.8 nTPM
  • pituitary gland: 0.5 nTPM
  • amygdala: 0.1 nTPM
  • breast: 0.1 nTPM
  • heart muscle: 0.1 nTPM
  • adipose tissue: 0 nTPM

Single-cell type

  • brain excitatory neurons: 134 nCPM
  • brain inhibitory neurons: 114 nCPM
  • other brain neurons: 60 nCPM
  • late spermatids: 40 nCPM
  • astrocytes: 36 nCPM
  • oligodendrocytes: 28 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 22 nTPM
  • cerebral cortex: 21 nTPM
  • basal ganglia: 19 nTPM
  • hippocampal formation: 18 nTPM
  • midbrain: 14 nTPM
  • thalamus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.29
gnomAD pLI
0
gnomAD missense Z
-0.8
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IQCJ as an antibody target. Whether an autoantibody or antibody against IQCJ could matter depends on whether native IQCJ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IQCJ is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IQCJ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IQCJ. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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