Seroatlas · Human Serome Atlas

IQCH

IQ domain-containing protein H

Also known as: FLJ12476, IQCH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86VS3
Gene: IQCH
Ensembl: ENSG00000103599
Chromosome: 15
Canonical length: 1027 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol,Mid piece

OverviewNCBI Gene

Predicted to act upstream of or within lncRNA transcription and single fertilization. Predicted to be active in nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1027 residues, UniProt reviewed canonical sequence.

>Q86VS3|IQCH
     1  MAQNTENHDP VGSILIQIHE DLYQLKEKLT KFSPEEKGET LDIQSLETAI KRTEVGLRIH
    61  IEKYLNVVNQ NVLTTSVNDE SLYTPQASKW LLPTVIDQKS FIFPQESEGT FWQPQRQHSS
   121  SLPVFPRAKI KVSKLIKGSN ISSLTVLPSS HCTDPYFTPI PVLQADAHKG ILSMIERGLI
   181  PPTARITFQN PPITPRAAPL HSFDEARKIP TVATFTIPRE PPPSPAEVKF FPKKQRSKGK
   241  SRRSRGHHDR KAMKVKTPLR ALKSLWDYDF LIYDGVIDNT APDFLAFKEH FSLAWGGIFS
   301  LLEHVEKFLR NYAIPEVKIK GNNLVALLPE FELTNKLTRY DLLSVLEDPA HVQMLINLPG
   361  QRYKGQDGNS EAAMKIQATW KCYKARKFFL FYRQQKWASG VIAIAWLLYC HKTRLKKILK
   421  ESRQRHLENF RIRAKHLAAN WNRIRTSRRT IIHIPSLGYS QPVREHIADF NTQQNMQLGR
   481  LCDILDANVN VIYICSHHMN DELVLYYKKI LSLHAAVKSG NLEDRSDLQD RFKIITPEAV
   541  NIFPKHHMCL ATHLMYSPKA IKRIKNLIRG TEAYIVSGLL HRDDLAVADM LDIPILGSEP
   601  ELAHLYSTKS GGKRVFDSAN VAVPPGIYDI YSQQQMIEQL SQLITDHLQI QRWLFKMDSE
   661  FRGNGTAFCD IPSYLKCYKW VLKESSRYGL EDWRKKWAQE PALVKISEEL AGILAQHAQP
   721  VNEKRFPTWR KFLQTFLSQG GVIEAFPPAD NVTNLTVDML IEPNGKISVL STGDQLHAES
   781  PFISSGTTVP QTSVDPQVLT YLCLQIGKAC RMRDVVGYFS IDLVTFIDPS TLEQQVWATG
   841  LNLAYSDQLA LTQLTLYLTN GHLDCSLSTL EVPRFVPKER KKTKCMSALS MPMLATSRYA
   901  VMTTQLRHSN LSLVFHYVFL QICRAHGIGY DVEERQGTVF ILYEHLKRHK LGMLTIGEDL
   961  QGVLMTFARH LFIIHQEISA PNMQGETNFK TTIADIETIL RVTKENKMRF EEEQQSKDDK
  1021  NLSKPKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IQCH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

testis: 11 nTPM
fallopian tube: 6.4 nTPM
retina: 4.6 nTPM
thyroid gland: 3.8 nTPM
parathyroid gland: 3.5 nTPM
epididymis: 2.4 nTPM

Single-cell type

respiratory ciliated cells: 468 nCPM
ependymal cells: 447 nCPM
early primary spermatocytes: 223 nCPM
fallopian tube ciliated cells: 192 nCPM
endometrial ciliated cells: 190 nCPM
myonuclei: 170 nCPM

Immune cell

MAIT T-cell: 0.3 nTPM
gdT-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
myeloid DC: 0.1 nTPM
naive B-cell: 0.1 nTPM

Brain region

choroid plexus: 11 nTPM
medulla oblongata: 7.6 nTPM
midbrain: 7 nTPM
spinal cord: 6.4 nTPM
hypothalamus: 6.2 nTPM
thalamus: 5.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: 0.77
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nuclear speck

Protein domainsUniProt · Pfam · InterPro

IQ domain-containing protein H
IQCH-like, ATP-grasp
IQCH-like, ATP-grasp

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IQCH as an antibody target. Whether an autoantibody or antibody against IQCH could matter depends on whether native IQCH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IQCH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IQCH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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