Seroatlas · Human Serome Atlas

IQCC

IQ domain-containing protein C

Also known as: FLJ10547, IQCC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q4KMZ1
Gene: IQCC
Ensembl: ENSG00000160051
Chromosome: 1
Canonical length: 466 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

No narrative summary is available for IQCC in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

466 residues, UniProt reviewed canonical sequence.

>Q4KMZ1|IQCC
     1  MEPELLVRKV SALQACVRGF LVRRQFQSLR AEYEAIVREV EGDLGTLQWT EGRIPRPRFL
    61  PEKAKSHQTW KAGDRVANPE QGLWNHFPCE ESEGEATWEE MVLKKSGESS ANQGSLCRDH
   121  SSWLQMKQNR KPSQEKTRDT TRMENPEATD QRLPHSQPQL QELQYHRSHL AMELLWLQQA
   181  INSRKEYLLL KQTLRSPEAG PIREEPRVFL EHGEQACERD QSQPSAPLED QSYRDRTTGE
   241  LEQEDDSCHR VKSPHRSPGS LATTQKNIAG AKCREPCYSK SGPPSSIPSN SQALGDRLTK
   301  GPDDGRQTFG GTCLLQMKIL EDQTPRGLKP RNHCPRKSRT QLSALYEDSN IKEMSPRKLD
   361  HKEPDCRTVR TQELGLSEDH IIWDGTLGGP EHSVLDLWRT KPPKGQAPTD RSSRDGTSNE
   421  PSHEGQKKQR TIPWRSKSPE ILSSTKAGCT GEEQWRGRPW KTEPPG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IQCC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 8.6 nTPM

Expression across tissuesHPA

Tissue

testis: 8.6 nTPM
epididymis: 4.1 nTPM
cerebellum: 3.8 nTPM
choroid plexus: 3.7 nTPM
pituitary gland: 3.5 nTPM
fallopian tube: 3.3 nTPM

Single-cell type

epicardial cells: 23 nCPM
early primary spermatocytes: 22 nCPM
breast lactating cells: 18 nCPM
late primary spermatocytes: 13 nCPM
fallopian tube ciliated cells: 11 nCPM
adrenal medulla cells: 11 nCPM

Immune cell

memory B-cell: 2.3 nTPM
NK-cell: 1.5 nTPM
T-reg: 1.5 nTPM
naive CD4 T-cell: 1.3 nTPM
memory CD4 T-cell: 1.2 nTPM
gdT-cell: 1.1 nTPM

Brain region

choroid plexus: 12 nTPM
cerebellum: 8 nTPM
basal ganglia: 6.3 nTPM
cerebral cortex: 6.2 nTPM
hippocampal formation: 6 nTPM
hypothalamus: 5.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
gnomAD missense Z: -0.32
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

IQ domain-containing protein C

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IQCC as an antibody target. Whether an autoantibody or antibody against IQCC could matter depends on whether native IQCC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IQCC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IQCC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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